iPTMnet Report for Q9C000 (NLRP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9C000 / NLRP1_HUMAN
Protein Name NACHT, LRR and PYD domains-containing protein 1
Gene Name Name: NLRP1
Synonyms:CARD7,DEFCAP;
Organism Homo sapiens (Human)

PRO ID PR:Q9C000
DAG View
PRO Name NACHT, LRR and PYD domains-containing protein 1 (human)
Definition A NACHT, LRR and PYD domains-containing protein 1 that is encoded in the genome of human.
Short Label hNLRP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9C000 (NLRP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T41 Phosphorylation PhosphoSitePlus
S93 Phosphorylation UniProt 35857590
S99 Phosphorylation UniProt 35857590
S101 Phosphorylation UniProt 35857590
S107 Phosphorylation PhosphoSitePlus   UniProt 35857590
T112 Phosphorylation UniProt 35857590
S113 Phosphorylation UniProt 35857590
T114 Phosphorylation UniProt 35857590
T129 Phosphorylation UniProt 35857590
S132 Phosphorylation UniProt 35857590
S163 Phosphorylation UniProt 35857590
S168 Phosphorylation UniProt 35857590
S170 Phosphorylation UniProt 35857590
S173 Phosphorylation UniProt 35857590
T178 Phosphorylation UniProt 35857590
S179 Phosphorylation UniProt 35857590
T180 Phosphorylation UniProt 35857590
T240 Phosphorylation PhosphoSitePlus
S291 Phosphorylation PhosphoSitePlus
K297 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
T993 Phosphorylation PhosphoSitePlus
T1000 Phosphorylation PhosphoSitePlus
S1017 Phosphorylation PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
K1428 Acetylation PhosphoSitePlus
K1439 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T965 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S113 Y113 Biomuta DOID:1324 / lung cancer [ cosmic ]
K297 N297 Biomuta DOID:1612 / breast cancer [ cosmic ]
K340 N340 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K826 N826 Biomuta DOID:1324 / lung cancer [ cosmic ]
T965 I965 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T993 A993 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T1000 M1000 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
T1000 K1000 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1371 L1371 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1439 R1439 Biomuta DOID:4159 / skin cancer [ cosmic ]