iPTMnet Report for Q9BZS1 (FOXP3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BZS1 / FOXP3_HUMAN
Protein Name Forkhead box protein P3
Gene Name Name: FOXP3
Synonyms:IPEX;ORFNames:JM2;
Organism Homo sapiens (Human)

PRO ID PR:Q9BZS1
DAG View
PRO Name forkhead box protein P3 (human)
Definition A forkhead box protein P3 that is encoded in the genome of human.
Short Label hFOXP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BZS1 (FOXP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus
R27 Methylation PhosphoSitePlus
K31 Acetylation PhosphoSitePlus   UniProt 22312127
K31 Ubiquitination PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
T44 Phosphorylation PhosphoSitePlus
R51 Methylation PhosphoSitePlus
T115 Phosphorylation PhosphoSitePlus
T138 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
R146 Methylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K250 Acetylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K252 Acetylation PhosphoSitePlus
K263 Acetylation PhosphoSitePlus   UniProt 22312127
K263 Ubiquitination PhosphoSitePlus
K268 Acetylation PhosphoSitePlus   UniProt 22312127
K268 Ubiquitination PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus
Y342 Phosphorylation PhosphoSitePlus   RLIMS-P   Signor 30011797, 24155921
Y342 Phosphorylation P06239 (LCK) PhosphoSitePlus   Signor 24155921
K356 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K393 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23396208, 30011797, 25096571
S422 Phosphorylation PhosphoSitePlus   RLIMS-P 25096571, 29352742
S422 Phosphorylation P11309 (PIM1) PhosphoSitePlus 25096571


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R51 * Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T138 I138 Biomuta [ cosmic ]
R146 W146 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R146 Q146 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ icgc ]