iPTMnet Report for Q9BZQ6 (EDEM3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BZQ6 / EDEM3_HUMAN
Protein Name ER degradation-enhancing alpha-mannosidase-like protein 3 precursor
Gene Name Name: EDEM3
Synonyms:C1orf22;
Organism Homo sapiens (Human)

PRO ID PR:Q9BZQ6
DAG View
PRO Name ER degradation-enhancing alpha-mannosidase-like protein 3 (human)
Definition An ER degradation-enhancing alpha-mannosidase-like protein 3 that is encoded in the genome of human.
Short Label hEDEM3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BZQ6 (EDEM3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K189 Ubiquitination PhosphoSitePlus
N195 N-Glycosylation GlyGen   UniProt 29741879, 19159218, 24190977
K208 Ubiquitination PhosphoSitePlus
K262 Ubiquitination PhosphoSitePlus
S286 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
Y296 Phosphorylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K555 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K594 Ubiquitination PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
N691 N-Glycosylation GlyGen 24190977
K705 Ubiquitination PhosphoSitePlus
K719 Ubiquitination PhosphoSitePlus
S835 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K262 N262 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K447 E447 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N691 D691 Biomuta DOID:4159 / skin cancer [ cosmic ]