Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BZL6 / KPCD2_HUMAN
Protein Name Serine/threonine-protein kinase D2
Gene Name Name: PRKD2
Synonyms:PKD2;ORFNames:HSPC187;
Organism Homo sapiens (Human)

PRO ID PR:Q9BZL6
DAG View
PRO Name serine/threonine-protein kinase D2 (human)
Definition A serine/threonine-protein kinase D2 that is encoded in the genome of human.
Short Label hPRKD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BZL6 (PRKD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K80 Ubiquitination PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus   RLIMS-P 28428613
K92 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
T101 Phosphorylation PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 23186163, 18220336, ...17192257, 18669648
S198 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16083285, 23186163
T199 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S200 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S203 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
S206 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18669648, 23186163
T211 Phosphorylation PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
S214 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17192257, 24275569
C217 S-Nitrosylation dbSNO 26338901
S225 Phosphorylation PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
S241 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
S244 Phosphorylation P48730 (CSNK1D) , P49674 (CSNK1E) PhosphoSitePlus   RLIMS-P   UniProt 17962809
S245 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
S374 Phosphorylation PhosphoSitePlus
S375 Phosphorylation PhosphoSitePlus
Y378 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
T392 Phosphorylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
T398 Phosphorylation PhosphoSitePlus
T412 Phosphorylation PhosphoSitePlus
K424 Ubiquitination PhosphoSitePlus
Y438 Phosphorylation P29597 (TYK2) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 28428613, 21865166, 15604256
S518 Phosphorylation PhosphoSitePlus   UniProt 19369195
S529 Phosphorylation PhosphoSitePlus
K572 Acetylation PhosphoSitePlus
K580 Acetylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K584 Acetylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
T619 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
K692 Ubiquitination PhosphoSitePlus
K705 Ubiquitination PhosphoSitePlus
S706 Phosphorylation Q02156 (PRKCE) , P17252 (PRKCA) , P24723 (PRKCH) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17962809, 28428613, 12058027
S710 Phosphorylation Q02156 (PRKCE) , P17252 (PRKCA) , P24723 (PRKCH) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 28428613, 23186163, ...12058027, 19369195, 17192257, 18669648, 17962809
T714 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y717 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19369195, 28428613, 18669648
S876 Phosphorylation P24723 (PRKCH) , Q9BZL6 (PRKD2) , P17252 (PRKCA) , Q13563 (PKD2) , Q02156 (PRKCE) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 11062248, 12058027, ...18691976, 23562655
Site PTM Type PTM Enzyme Score Source PMID
S197 Phosphorylation HPRD 18691976, 16083285, 19651622, ...17322306, 18669648, 20166139
S198 Phosphorylation HPRD 20166139, 18691976, 18669648, ...16083285, 20068231
T199 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
S200 Phosphorylation HPRD 20166139, 18669648, 17192257
S203 Phosphorylation HPRD 18669648
S206 Phosphorylation HPRD 18669648
S214 Phosphorylation HPRD 19413330, 18691976, 18669648
S236 Phosphorylation HPRD 18691976
S353 Phosphorylation HPRD 18691976
S375 Phosphorylation HPRD 18691976
S396 Phosphorylation HPRD 18691976
S518 Phosphorylation HPRD 18691976
S706 Phosphorylation HPRD 18691976, 17192257
S710 Phosphorylation HPRD 18691976, 18669648, 17192257
T714 Phosphorylation HPRD 18669648
Y717 Phosphorylation HPRD 18669648
S876 Phosphorylation Q9BZL6 (PRKD2) HPRD 18691976, 11062248
Site PTM Type PTM Enzyme Score Source PMID
S40 Phosphorylation HPRD 17322306, 18691976, 18669648, ...20166139, 19651622
S41 Phosphorylation HPRD 20166139, 18691976, 18669648, ...20068231
T42 Phosphorylation HPRD 20166139, 18669648, 17081983, ...20068231
S43 Phosphorylation HPRD 20166139, 18669648, 17192257
S46 Phosphorylation HPRD 18669648
S49 Phosphorylation HPRD 18669648
S57 Phosphorylation HPRD 19413330, 18691976, 18669648
S79 Phosphorylation HPRD 18691976
S196 Phosphorylation HPRD 18691976
S218 Phosphorylation HPRD 18691976
S239 Phosphorylation HPRD 18691976
S361 Phosphorylation HPRD 18691976
S549 Phosphorylation HPRD 18691976, 17192257
S553 Phosphorylation HPRD 18691976, 18669648, 17192257
T557 Phosphorylation HPRD 18669648
Y560 Phosphorylation HPRD 18669648
S719 Phosphorylation HPRD 18691976


Q9BZL6 (PRKD2) as PTM Enzyme



Substrate Site Score Source PMID
P16144-2 (ITGB4) T1736 PhosphoSitePlus 26580203
P17181 (IFNAR1) S535 neXtProt 21865166
P50552 (VASP) S157 PhosphoSitePlus 26336132
P50552 (VASP) S239 PhosphoSitePlus 26336132
P50552 (VASP) S322 PhosphoSitePlus 26336132
Q01105-2 (SET) S171 neXtProt   PhosphoSitePlus 23251465
Q13563 (PKD2) S801 PhosphoSitePlus 20881056
Q13671 (RIN1) S292 PhosphoSitePlus 21209314
Q7KZI7 (MARK2) S400 PhosphoSitePlus 19011111
Q8WYL5 (SSH1) S937 PhosphoSitePlus   Signor 21525957, 19567672
Q8WYL5 (SSH1) S978 PhosphoSitePlus 19567672
Q99828 (CIB1) S78 PhosphoSitePlus 23503467
Q9BST9 (RTKN) S448 neXtProt 22228765
Q9BZL6 (PRKD2) S876 HPRD   PhosphoSitePlus   Signor   UniProt 18691976, 11062248
Q9UBF8-2 (PI4KB) S294 neXtProt   PhosphoSitePlus   Signor 16912074, 16100512
Q9UQL6 (HDAC5) S498 neXtProt   PhosphoSitePlus 16584705


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T101 K101 Biomuta DOID:3571 / liver cancer [ icgc ]
T199 M199 Biomuta DOID:363 / uterine cancer [ tcga ]
S200 Y200 Biomuta DOID:3571 / liver cancer [ icgc ]
S203 C203 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S203 T203 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S206 L206 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T211 N211 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S355 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S374 G374 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
K424 E424 Biomuta DOID:1324 / lung cancer [ tcga ]
S518 N518 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S529 F529 Biomuta DOID:1909 / melanoma [ tcga ]
K643 N643 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S706 L706 Biomuta DOID:1909 / melanoma [ tcga ]
S876 G876 Biomuta DOID:1324 / lung cancer [ cosmic ]