iPTMnet Report Q9BZL6 PRKD2

Protein Information

UniProt AC / UniProt ID	Q9BZL6 / KPCD2_HUMAN
Protein Name	Serine/threonine-protein kinase D2
Gene Name	Name: PRKD2 Synonyms:PKD2;ORFNames:HSPC187;
Organism	Homo sapiens (Human)

PRO ID	PR:Q9BZL6 DAG View
PRO Name	serine/threonine-protein kinase D2 (human)
Definition	A serine/threonine-protein kinase D2 that is encoded in the genome of human.
Short Label	hPRKD2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

Q9BZL6 (PRKD2) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position K80 Y87 K92 K97 T101 K178 S183 S189 S197 S198 T199 S200 S203 S206 T211 S212 S214 C217 S225 T227 S236 S237 S238 S239 S241 S242 S244 S245 Y246 K255 K260 Y272 K286 S355 S362 S374 S375 Y378 S387 T391 T392 S395 S396 T398 T412 K424 Y438 S518 S529 K572 K580 K584 T589 K590 T619 K643 K676 K692 K705 S706 S710 T714 Y717 S876	PTM Type Select all Acetylation O-Glycosylation Phosphorylation S-Nitrosylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all GlyGen IEDB PhosphoSitePlus RLIMS-P Signor UniProt dbSNO neXtProt phospho.ELM	PMID
K80	Ubiquitination		score1	PhosphoSitePlus
Y87	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28428613
K92	Ubiquitination		score1	PhosphoSitePlus
K97	Ubiquitination		score1	PhosphoSitePlus
T101	Phosphorylation		score1	PhosphoSitePlus
K178	Ubiquitination		score1	PhosphoSitePlus
S183	Phosphorylation		score1	PhosphoSitePlus
S189	Phosphorylation		score1	PhosphoSitePlus
S197	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	16083285, 23186163, 18220336, ...17192257, 18669648
S198	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 16083285, 23186163
T199	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
S200	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163
S203	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 23186163, 21406692
S206	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	19369195, 18669648, 23186163
T211	Phosphorylation		score1	PhosphoSitePlus
S212	Phosphorylation		score1	PhosphoSitePlus
S214	Phosphorylation		score2	phospho.ELM PhosphoSitePlus UniProt	18669648, 24275569, 17192257
C217	S-Nitrosylation		score0	dbSNO	26338901
S225	Phosphorylation		score1	PhosphoSitePlus
T227	Phosphorylation		score1	PhosphoSitePlus
S236	Phosphorylation		score1	PhosphoSitePlus
S237	Phosphorylation		score1	PhosphoSitePlus
S238	Phosphorylation		score1	PhosphoSitePlus
S239	Phosphorylation		score1	PhosphoSitePlus
S241	Phosphorylation		score1	PhosphoSitePlus
S242	Phosphorylation		score1	PhosphoSitePlus
S244	Phosphorylation	P48730 (CSNK1D) , P49674 (CSNK1E)	score3	PhosphoSitePlus UniProt	17962809
S245	Phosphorylation		score1	PhosphoSitePlus
Y246	Phosphorylation		score1	PhosphoSitePlus
K255	Ubiquitination		score1	PhosphoSitePlus
K260	Ubiquitination		score1	PhosphoSitePlus
Y272	Phosphorylation		score1	PhosphoSitePlus
K286	Ubiquitination		score1	PhosphoSitePlus
S355	Phosphorylation		score1	PhosphoSitePlus
S362	Phosphorylation		score1	PhosphoSitePlus
S374	Phosphorylation		score1	PhosphoSitePlus
S375	Phosphorylation		score1	PhosphoSitePlus
Y378	Phosphorylation		score1	PhosphoSitePlus
S387	Phosphorylation		score1	PhosphoSitePlus
T391	Phosphorylation		score1	PhosphoSitePlus
T392	Phosphorylation		score1	PhosphoSitePlus
S395	O-Glycosylation		score1	GlyGen	22564745, 35254053
S395	Phosphorylation		score1	PhosphoSitePlus
S396	O-Glycosylation		score1	GlyGen	22564745, 35254053
S396	Phosphorylation		score1	PhosphoSitePlus
T398	Phosphorylation		score1	PhosphoSitePlus
T412	Phosphorylation		score1	PhosphoSitePlus
K424	Ubiquitination		score1	PhosphoSitePlus
Y438	Phosphorylation	P29597 (TYK2)	score4	neXtProt PhosphoSitePlus RLIMS-P UniProt	28428613, 21865166, 15604256
S518	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
S529	Phosphorylation		score2	IEDB PhosphoSitePlus	30784271
K572	Acetylation		score1	PhosphoSitePlus
K580	Acetylation		score1	PhosphoSitePlus
K580	Ubiquitination		score1	PhosphoSitePlus
K584	Acetylation		score1	PhosphoSitePlus
T589	Phosphorylation		score1	IEDB	35494241
K590	Ubiquitination		score1	PhosphoSitePlus
T619	Phosphorylation		score1	PhosphoSitePlus
K643	Ubiquitination		score1	PhosphoSitePlus
K676	Ubiquitination		score1	PhosphoSitePlus
K692	Ubiquitination		score1	PhosphoSitePlus
K705	Ubiquitination		score1	PhosphoSitePlus
S706	Phosphorylation	Q02156 (PRKCE) , P17252 (PRKCA) , P24723 (PRKCH)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	28428613, 12058027
S710	Phosphorylation	Q02156 (PRKCE) , P17252 (PRKCA) , P24723 (PRKCH)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18691976, 28428613, 23186163, ...12058027, 19369195, 17192257, 18669648
T714	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18669648
Y717	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P UniProt	19369195, 18669648, 28428613
S876	Phosphorylation	P24723 (PRKCH) , Q9BZL6 (PRKD2) , P17252 (PRKCA) , Q02156 (PRKCE) , Q13563 (PKD2)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	18691976, 11062248, 12058027, ...19369195, 23562655, 30718593

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S197 S198 T199 S200 S203 S206 S214 S236 S353 S375 S396 S518 S706 S710 T714 Y717 S876	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 2	Source Select all HPRD	PMID
S197	Phosphorylation		score0	HPRD	18691976, 16083285, 19651622, ...17322306, 18669648, 20166139
S198	Phosphorylation		score0	HPRD	20166139, 18691976, 18669648, ...16083285, 20068231
T199	Phosphorylation		score0	HPRD	20166139, 18669648, 17081983, ...20068231
S200	Phosphorylation		score0	HPRD	20166139, 18669648, 17192257
S203	Phosphorylation		score0	HPRD	18669648
S206	Phosphorylation		score0	HPRD	18669648
S214	Phosphorylation		score0	HPRD	19413330, 18691976, 18669648
S236	Phosphorylation		score0	HPRD	18691976
S353	Phosphorylation		score0	HPRD	18691976
S375	Phosphorylation		score0	HPRD	18691976
S396	Phosphorylation		score0	HPRD	18691976
S518	Phosphorylation		score0	HPRD	18691976
S706	Phosphorylation		score0	HPRD	18691976, 17192257
S710	Phosphorylation		score0	HPRD	18691976, 18669648, 17192257
T714	Phosphorylation		score0	HPRD	18669648
Y717	Phosphorylation		score0	HPRD	18669648
S876	Phosphorylation	Q9BZL6 (PRKD2)	score2	HPRD	18691976, 11062248

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S40 S41 T42 S43 S46 S49 S57 S79 S196 S218 S239 S361 S549 S553 T557 Y560 S719	PTM Type Select all Phosphorylation	Score Select all 0	Source Select all HPRD	PMID
S40	Phosphorylation	score0	HPRD	17322306, 18691976, 18669648, ...20166139, 19651622
S41	Phosphorylation	score0	HPRD	20166139, 18691976, 18669648, ...20068231
T42	Phosphorylation	score0	HPRD	20166139, 18669648, 17081983, ...20068231
S43	Phosphorylation	score0	HPRD	20166139, 18669648, 17192257
S46	Phosphorylation	score0	HPRD	18669648
S49	Phosphorylation	score0	HPRD	18669648
S57	Phosphorylation	score0	HPRD	19413330, 18691976, 18669648
S79	Phosphorylation	score0	HPRD	18691976
S196	Phosphorylation	score0	HPRD	18691976
S218	Phosphorylation	score0	HPRD	18691976
S239	Phosphorylation	score0	HPRD	18691976
S361	Phosphorylation	score0	HPRD	18691976
S549	Phosphorylation	score0	HPRD	18691976, 17192257
S553	Phosphorylation	score0	HPRD	18691976, 18669648, 17192257
T557	Phosphorylation	score0	HPRD	18669648
Y560	Phosphorylation	score0	HPRD	18669648
S719	Phosphorylation	score0	HPRD	18691976

Q9BZL6 (PRKD2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Search:

Substrate Select all P16144-2 (ITGB4) P17181 (IFNAR1) P50552 (VASP) Q01105-2 (SET) Q13563 (PKD2) Q13671 (RIN1) Q7KZI7 (MARK2) Q8WYL5 (SSH1) Q99828 (CIB1) Q9BST9 (RTKN) Q9BZL6-1 (PRKD2) Q9UBF8-2 (PI4KB) Q9UQL6 (HDAC5)	Site Select all By amino acid All Serine All Threonine By position S78 S157 S171 S239 S292 S294 S322 S400 S448 S498 S535 S801 S876 S937 S978 T1736	Score Select all 2 3 4	Source Select all HPRD PhosphoSitePlus Signor UniProt neXtProt	PMID
P16144-2 (ITGB4)	T1736	score2	PhosphoSitePlus	26580203
P17181 (IFNAR1)	S535	score2	neXtProt	21865166
P50552 (VASP)	S157	score2	PhosphoSitePlus	26336132
P50552 (VASP)	S239	score2	PhosphoSitePlus	26336132
P50552 (VASP)	S322	score2	PhosphoSitePlus	26336132
Q01105-2 (SET)	S171	score3	neXtProt PhosphoSitePlus	23251465
Q13563 (PKD2)	S801	score2	PhosphoSitePlus	20881056
Q13671 (RIN1)	S292	score2	PhosphoSitePlus	21209314
Q7KZI7 (MARK2)	S400	score2	PhosphoSitePlus	19011111
Q8WYL5 (SSH1)	S937	score4	PhosphoSitePlus Signor	21525957, 19567672
Q8WYL5 (SSH1)	S978	score2	PhosphoSitePlus	19567672
Q99828 (CIB1)	S78	score2	PhosphoSitePlus	23503467
Q9BST9 (RTKN)	S448	score2	neXtProt	22228765
Q9BZL6-1 (PRKD2)	S876	score4	HPRD PhosphoSitePlus Signor UniProt	18691976, 11062248
Q9UBF8-2 (PI4KB)	S294	score4	neXtProt PhosphoSitePlus Signor	16912074, 16100512
Q9UQL6 (HDAC5)	S498	score3	neXtProt PhosphoSitePlus	16584705

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S46 S49 S183 S189 S203 S206 T211 S237 S239 S241 K255 K260 S355 S361 S374 T391 S395 K424 S518 S529 S549 S553 T619 K643 S706 S710 S719 S876	Variant Select all * C189 C203 C46 E424 F237 F239 F395 F529 G374 G719 G876 I203 I46 L206 L49 L549 L553 L706 L710 M255 M391 M619 N183 N211 N361 N518 N643 Q260 T203 T46 Y241	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ] DOID:2021 / placenta cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:3953 / adrenal gland cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S46	T46	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S46	I46	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S46	C46	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S49	L49	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S183	N183	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S189	C189	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S203	C203	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S203	I203	Biomuta	DOID:4606 / bile duct cancer [ cosmic ]
S203	T203	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S206	L206	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T211	N211	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc ]
S237	F237	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S239	F239	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S241	Y241	Biomuta	DOID:3953 / adrenal gland cancer [ cosmic ]
K255	M255	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
K260	Q260	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
S355	*	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S361	N361	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S374	G374	Biomuta	DOID:263 / kidney cancer [ cosmic ]
T391	M391	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S395	F395	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
K424	E424	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S518	N518	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S529	F529	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S549	L549	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S553	L553	Biomuta	DOID:2021 / placenta cancer [ cosmic ]
T619	M619	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K643	N643	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S706	L706	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S710	L710	Biomuta	DOID:2021 / placenta cancer [ cosmic ]
S719	G719	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S876	G876	Biomuta	DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for Q9BZL6 (PRKD2)

Protein Information

Interactive Sequence View

Q9BZL6 (PRKD2) as Substrate

Q9BZL6 (PRKD2) as PTM Enzyme

PTM sites affected in variants