Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BZK7 / TBL1R_HUMAN
Protein Name F-box-like/WD repeat-containing protein TBL1XR1
Gene Name Name: TBL1XR1
Synonyms:IRA1,TBLR1;
Organism Homo sapiens (Human)

PRO ID PR:Q9BZK7
DAG View
PRO Name F-box-like/WD repeat-containing protein TBL1XR1 (human)
Definition An F-box-like/WD repeat-containing protein TBL1XR1 that is encoded in the genome of human.
Short Label hTBL1XR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BZK7 (TBL1XR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 22814378, 22223895
K102 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S119 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 20068231
S123 Phosphorylation PhosphoSitePlus   Signor 18374649
S123 Phosphorylation Q05655 (PRKCD) PhosphoSitePlus   Signor 18374649
S199 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
K254 Acetylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
K277 Sumoylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
R431 Methylation PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K464 Methylation PhosphoSitePlus
K497 Sumoylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S119 N119 Biomuta DOID:2531 / hematologic cancer [ tcga ] DOID:11934 / head and neck cancer [ icgc, tcga ]
S199 G199 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T203 N203 Biomuta DOID:363 / uterine cancer [ tcga ]
K277 T277 Biomuta DOID:363 / uterine cancer [ tcga ]
R431 Q431 Biomuta DOID:4362 / cervical cancer [ tcga ]
R431 * Biomuta DOID:3571 / liver cancer [ tcga ]
R431 L431 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y446 H446 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y446 C446 Biomuta DOID:2531 / hematologic cancer [ icgc, tcga ]
K497 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]