iPTMnet Report for Q9BZD4 (NUF2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BZD4 / NUF2_HUMAN
Protein Name Kinetochore protein Nuf2
Gene Name Name: NUF2
Synonyms:CDCA1,NUF2R;
Organism Homo sapiens (Human)

PRO ID PR:Q9BZD4
DAG View
PRO Name kinetochore protein Nuf2 (human)
Definition A kinetochore protein Nuf2 that is encoded in the genome of human.
Short Label hNUF2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BZD4 (NUF2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K21 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
Y37 Phosphorylation PhosphoSitePlus
C99 Methylation IEDB 31844290
C111 Methylation IEDB 31844290
K113 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus   UniProt 23186163
K181 Ubiquitination PhosphoSitePlus
S184 Phosphorylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
K212 Ubiquitination PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S247 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 32897882, 23186163, 17081983, ...35561310, 19691289, 16565220, 22067460, 18669648, 19007248, 19415658, 20068231
K250 Ubiquitination PhosphoSitePlus
T261 Phosphorylation HPRD   PhosphoSitePlus 17924679
K299 Ubiquitination PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
S329 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
C377 Methylation IEDB 31844290
K379 Ubiquitination PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
Y388 Phosphorylation PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O14777 (hNDC80) Interaction PR:Q9BZD4 (hNUF2) PRO
PR:Q02224 (hCENPE) Interaction PR:Q9BZD4 (hNUF2) PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K113 Q113 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S171 Y171 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S171 F171 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S210 F210 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S247 Y247 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
T261 M261 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K309 T309 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K335 N335 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
C377 Y377 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K409 Q409 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K409 N409 Biomuta DOID:5158 / pleural cancer [ cosmic ]