Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BYX4 / IFIH1_HUMAN
Protein Name Interferon-induced helicase C domain-containing protein 1
Gene Name Name: IFIH1
Synonyms:MDA5,RH116;
Organism Homo sapiens (Human)

PRO ID PR:Q9BYX4
DAG View
PRO Name interferon-induced helicase C domain-containing protein 1 (human)
Definition An interferon-induced helicase C domain-containing protein 1 that is encoded in the genome of human.
Short Label hIFIH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BYX4 (IFIH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Sumoylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K174 Ubiquitination PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
K351 Acetylation PhosphoSitePlus
K352 Acetylation PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
Y385 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K529 Ubiquitination PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
K700 Ubiquitination PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K743 Ubiquitination PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
S828 Phosphorylation O14730 (RIOK3) PhosphoSitePlus   UniProt 25865883
K865 Sumoylation PhosphoSitePlus
Y896 Phosphorylation PhosphoSitePlus
S1022 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T100 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T100 M100 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
T100 A100 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K351 E351 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K352 N352 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S354 F354 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S645 T645 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K777 R777 Biomuta DOID:10534 / stomach cancer [ tcga ]
S828 R828 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y896 C896 Biomuta DOID:1324 / lung cancer [ tcga ]