iPTMnet Report for Q9BYW2 (SETD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BYW2 / SETD2_HUMAN
Protein Name Histone-lysine N-methyltransferase SETD2
Gene Name Name: SETD2
Synonyms:HIF1,HYPB;ORFNames:HSPC069;
Organism Homo sapiens (Human)

PRO ID PR:Q9BYW2
DAG View
PRO Name histone-lysine N-methyltransferase SETD2 (human)
Definition A histone-lysine N-methyltransferase SETD2 that is encoded in the genome of human.
Short Label hSETD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BYW2 (SETD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T38 Phosphorylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
K47 Methylation PhosphoSitePlus
S51 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
T126 Phosphorylation PhosphoSitePlus
S130 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S131 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
S301 Phosphorylation PhosphoSitePlus
S321 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 19690332, 20068231
S323 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...19690332, 20068231
S327 Phosphorylation PhosphoSitePlus
S344 Phosphorylation PhosphoSitePlus   UniProt 23186163
K359 Sumoylation PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
R411 Methylation PhosphoSitePlus
S418 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y427 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
S461 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
Y480 Phosphorylation PhosphoSitePlus
T485 Phosphorylation PhosphoSitePlus
S532 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S543 Phosphorylation PhosphoSitePlus
S546 O-Glycosylation GlyGen 23301498, 30379171, 28411811
Y555 Phosphorylation PhosphoSitePlus
K556 Methylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
T592 Phosphorylation PhosphoSitePlus
S614 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
S618 Phosphorylation PhosphoSitePlus
S624 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
T626 Phosphorylation PhosphoSitePlus   UniProt 23186163
K629 Ubiquitination PhosphoSitePlus
K637 Sumoylation PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
T642 Phosphorylation PhosphoSitePlus
S648 Phosphorylation PhosphoSitePlus
K650 Ubiquitination PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
K659 Ubiquitination PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S698 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
S708 Phosphorylation PhosphoSitePlus   UniProt 19690332
S725 Phosphorylation PhosphoSitePlus
S742 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S744 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332
T749 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S754 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 19690332
Y770 Phosphorylation PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
C795 Methylation IEDB 31844290
S800 Phosphorylation PhosphoSitePlus
S823 Phosphorylation PhosphoSitePlus
K899 Ubiquitination PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus
K922 Ubiquitination PhosphoSitePlus
T928 Phosphorylation PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
K941 Acetylation PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
S980 Phosphorylation PhosphoSitePlus
S1032 Phosphorylation PhosphoSitePlus
T1033 Phosphorylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus
T1083 Phosphorylation PhosphoSitePlus
S1084 Phosphorylation PhosphoSitePlus
S1098 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1113 Phosphorylation PhosphoSitePlus
K1116 Ubiquitination PhosphoSitePlus
S1119 Phosphorylation PhosphoSitePlus
T1137 Phosphorylation PhosphoSitePlus
S1144 Phosphorylation PhosphoSitePlus
S1149 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus
S1178 Phosphorylation PhosphoSitePlus
S1186 Phosphorylation PhosphoSitePlus
T1189 Phosphorylation PhosphoSitePlus
S1196 Phosphorylation PhosphoSitePlus
S1206 Phosphorylation PhosphoSitePlus
S1207 Phosphorylation PhosphoSitePlus
K1215 Ubiquitination PhosphoSitePlus
S1216 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 30784271, ...18220336
S1236 Phosphorylation PhosphoSitePlus
S1263 Phosphorylation PhosphoSitePlus
K1266 Ubiquitination PhosphoSitePlus
K1285 Ubiquitination PhosphoSitePlus
S1366 Phosphorylation PhosphoSitePlus
K1399 Acetylation PhosphoSitePlus
S1413 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 15302935
S1415 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1417 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K1461 Methylation PhosphoSitePlus
K1465 Methylation PhosphoSitePlus
K1468 Methylation PhosphoSitePlus
Y1481 Phosphorylation PhosphoSitePlus
T1483 Phosphorylation PhosphoSitePlus
K1489 Methylation PhosphoSitePlus
K1620 Ubiquitination PhosphoSitePlus
C1635 Methylation IEDB 31844290
R1686 Methylation PhosphoSitePlus
S1696 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1792 Phosphorylation PhosphoSitePlus
K1802 Acetylation PhosphoSitePlus
K1812 Acetylation PhosphoSitePlus
T1832 Phosphorylation PhosphoSitePlus
S1844 Phosphorylation PhosphoSitePlus
S1845 Phosphorylation PhosphoSitePlus
S1849 Phosphorylation PhosphoSitePlus
T1853 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T1857 Phosphorylation PhosphoSitePlus
T1870 Phosphorylation PhosphoSitePlus
T1872 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S1888 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1891 Phosphorylation PhosphoSitePlus
S1894 Phosphorylation PhosphoSitePlus
S1898 Phosphorylation PhosphoSitePlus
S1925 Phosphorylation PhosphoSitePlus
S1940 Phosphorylation PhosphoSitePlus
T1942 Phosphorylation PhosphoSitePlus
T1951 Phosphorylation PhosphoSitePlus
S1952 Phosphorylation PhosphoSitePlus   UniProt 23186163
T1978 Phosphorylation PhosphoSitePlus
S1980 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1988 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1992 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1995 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T2010 Phosphorylation PhosphoSitePlus
T2036 Phosphorylation PhosphoSitePlus
T2051 Phosphorylation PhosphoSitePlus
T2056 Phosphorylation PhosphoSitePlus
S2079 Phosphorylation PhosphoSitePlus
S2080 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S2082 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
S2086 Phosphorylation PhosphoSitePlus
Y2088 Phosphorylation PhosphoSitePlus
T2092 Phosphorylation PhosphoSitePlus
Y2099 Phosphorylation PhosphoSitePlus
T2101 Phosphorylation PhosphoSitePlus
S2104 Phosphorylation PhosphoSitePlus
T2388 O-Glycosylation GlyGen 23301498, 30379171, 28411811
T2421 Phosphorylation PhosphoSitePlus
S2424 Phosphorylation PhosphoSitePlus
S2430 Phosphorylation PhosphoSitePlus
T2441 Phosphorylation PhosphoSitePlus
T2443 Phosphorylation PhosphoSitePlus
S2464 Phosphorylation PhosphoSitePlus
K2546 Acetylation PhosphoSitePlus
K2558 Acetylation PhosphoSitePlus
T2561 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S130 Phosphorylation HPRD 18669648, 20068231
S131 Phosphorylation HPRD 19413330, 19664995, 18452278, ...19651622, 18669648, 20068231
S321 Phosphorylation HPRD 19413330, 18669648, 20068231, ...18452278
S323 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231, 18452278
S532 Phosphorylation HPRD 19664994, 19664995
S614 Phosphorylation HPRD 19413330
S624 Phosphorylation HPRD 19413330, 18767875, 18669648, ...20068231
T626 Phosphorylation HPRD 19651622
S654 Phosphorylation HPRD 18767875
S656 Phosphorylation HPRD 18767875
S698 Phosphorylation HPRD 20068231
S701 Phosphorylation HPRD 20068231
S708 Phosphorylation HPRD 19413330
S742 Phosphorylation HPRD 19651622, 18669648, 20068231
S744 Phosphorylation HPRD 18669648
S754 Phosphorylation HPRD 18669648, 20068231
S905 Phosphorylation HPRD 19413330
S1084 Phosphorylation HPRD 19664995
S1206 Phosphorylation HPRD 18452278
S1228 Phosphorylation HPRD 18669648
S1413 Phosphorylation HPRD 18669648
S1415 Phosphorylation HPRD 18669648
S1417 Phosphorylation HPRD 19651622, 18669648, 18452278
T1853 Phosphorylation HPRD 20068231
T1872 Phosphorylation HPRD 18669648, 20068231
S1888 Phosphorylation HPRD 18452278
S1898 Phosphorylation HPRD 18452278
S1952 Phosphorylation HPRD 18452278
S1980 Phosphorylation HPRD 18669648
S1988 Phosphorylation HPRD 18669648, 18452278
S1992 Phosphorylation HPRD 18669648, 18452278
S1995 Phosphorylation HPRD 18669648, 18452278
S2080 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S2082 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S52 N52 Biomuta DOID:263 / kidney cancer [ cosmic ]
T126 A126 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S130 Y130 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S301 C301 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S418 Y418 Biomuta DOID:263 / kidney cancer [ cosmic ]
S418 F418 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S461 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S470 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S543 * Biomuta DOID:263 / kidney cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T592 K592 Biomuta DOID:3571 / liver cancer [ cosmic ]
S618 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S624 P624 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K629 E629 Biomuta [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
K629 M629 Biomuta DOID:1324 / lung cancer [ cosmic ]
K637 N637 Biomuta DOID:1324 / lung cancer [ cosmic ]
T642 A642 Biomuta DOID:1612 / breast cancer [ cosmic ]
K657 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S698 F698 Biomuta DOID:1324 / lung cancer [ cosmic ]
S701 N701 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S742 * Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S754 L754 Biomuta DOID:1612 / breast cancer [ cosmic ]
C795 R795 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S800 R800 Biomuta DOID:4159 / skin cancer [ cosmic ]
K899 * Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S918 * Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S980 C980 Biomuta DOID:1612 / breast cancer [ cosmic ]
S980 F980 Biomuta DOID:4159 / skin cancer [ cosmic ]
S980 P980 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1033 A1033 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1084 N1084 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y1113 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K1116 E1116 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1186 P1186 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1206 F1206 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1207 F1207 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1207 C1207 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S1228 G1228 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1236 N1236 Biomuta DOID:1612 / breast cancer [ cosmic ]
K1266 R1266 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K1468 N1468 Biomuta DOID:363 / uterine cancer [ icgc ]
K1489 T1489 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1489 E1489 Biomuta [ cosmic ] DOID:1319 / brain cancer [ icgc ]
K1620 Q1620 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1620 N1620 Biomuta DOID:5158 / pleural cancer [ cosmic ]
C1635 R1635 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R1686 W1686 Biomuta DOID:4159 / skin cancer [ cosmic ]
R1686 P1686 Biomuta DOID:263 / kidney cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
R1686 Q1686 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1792 N1792 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1832 S1832 Biomuta DOID:184 / bone cancer [ cosmic ]
S1849 L1849 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
T1857 A1857 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1888 N1888 Biomuta DOID:363 / uterine cancer [ icgc ]
S1894 C1894 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1894 F1894 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1898 N1898 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1925 L1925 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S1940 R1940 Biomuta DOID:1612 / breast cancer [ cosmic ]
T1951 I1951 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T1951 K1951 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1952 F1952 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S2082 L2082 Biomuta DOID:1324 / lung cancer [ cosmic ]
S2082 * Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
Y2099 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S2104 F2104 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S2104 C2104 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
T2421 A2421 Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
T2441 I2441 Biomuta DOID:4159 / skin cancer [ cosmic ]