iPTMnet Report for Q9BYP7 (WNK3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BYP7 / WNK3_HUMAN
Protein Name Serine/threonine-protein kinase WNK3
Gene Name Name: WNK3
Synonyms:KIAA1566;
Organism Homo sapiens (Human)

PRO ID PR:Q9BYP7
DAG View
PRO Name serine/threonine-protein kinase WNK3 (human)
Definition A serine/threonine-protein kinase WNK3 that is encoded in the genome of human.
Short Label hWNK3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BYP7 (WNK3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S62 Phosphorylation PhosphoSitePlus   UniProt 21406692
T140 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S143 Phosphorylation PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
T234 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
S308 Phosphorylation PhosphoSitePlus   UniProt 33439774
S308 Phosphorylation Q9BYP7 (WNK3) UniProt 33439774
K439 Acetylation PhosphoSitePlus
K443 Acetylation PhosphoSitePlus
K468 Acetylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
T489 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
T525 Phosphorylation PhosphoSitePlus
T541 Phosphorylation PhosphoSitePlus   UniProt 35179207
S682 Phosphorylation PhosphoSitePlus
S701 Phosphorylation PhosphoSitePlus
T709 O-Glycosylation GlyGen 33214551, 35138101, 21740066, ...30620550, 34019948, 20305658, 28657654
S734 Phosphorylation PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus
T974 O-Glycosylation GlyGen 33214551, 35138101, 21740066, ...30620550, 34019948, 20305658, 28657654
T1312 O-Glycosylation GlyGen 33214551, 35138101, 21740066, ...30620550, 34019948, 20305658, 28657654
S1315 Phosphorylation PhosphoSitePlus
S1329 Phosphorylation PhosphoSitePlus
R1334 Methylation PhosphoSitePlus
T1341 Phosphorylation PhosphoSitePlus
S1395 Phosphorylation PhosphoSitePlus
S1471 Phosphorylation PhosphoSitePlus
S1576 Phosphorylation PhosphoSitePlus
S1585 Phosphorylation PhosphoSitePlus
S1638 Phosphorylation PhosphoSitePlus   UniProt 24275569
K1652 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1471 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S1631 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S1424 Phosphorylation HPRD 19413330


Q9BYP7 (WNK3) as PTM Enzyme



Substrate Site Score Source PMID
P55011 (SLC12A2) T212 neXtProt 16275911
P55011 (SLC12A2) T217 neXtProt 16275911
Q13621 (SLC12A1) T100 neXtProt 16275913
Q13621 (SLC12A1) T105 neXtProt 16275913
Q9BYP7 (WNK3) S308 UniProt 33439774
Q9H4A3 (WNK1) S382 neXtProt   PhosphoSitePlus   Signor 22032326
Q9UHW9 (SLC12A6) S96 PhosphoSitePlus   Signor 24043619
Q9UHW9 (SLC12A6) T991 PhosphoSitePlus   Signor 24043619
Q9UHW9 (SLC12A6) T1048 PhosphoSitePlus   Signor 24043619


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S232 F232 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S252 I252 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S308 I308 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K439 I439 Biomuta DOID:4159 / skin cancer [ icgc ]
K439 N439 Biomuta DOID:4159 / skin cancer [ icgc ] DOID:1612 / breast cancer [ cosmic ]
K443 R443 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
S475 I475 Biomuta DOID:1324 / lung cancer [ cosmic ]
T489 M489 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ]
S509 C509 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T541 A541 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T709 M709 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S905 N905 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R1334 W1334 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1395 Y1395 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1576 F1576 Biomuta DOID:4159 / skin cancer [ cosmic ]