iPTMnet Report for Q9BYK8 (HELZ2)
Protein Information
| UniProt AC / UniProt ID | Q9BYK8 / HELZ2_HUMAN |
| Protein Name | Helicase with zinc finger domain 2 |
| Gene Name | Name: HELZ2 Synonyms:KIAA1769,PRIC285; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9BYK8 |
| PRO Name | helicase with zinc finger domain 2 (human) |
| Definition | A helicase with zinc finger domain 2 that is encoded in the genome of human. |
| Short Label | hHELZ2 |
| Category | organism-gene |
Q9BYK8 (HELZ2) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C59 | Methylation | score1 | IEDB | 31844290 | ||
| C166 | Methylation | score1 | IEDB | 31844290 | ||
| S334 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S338 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 15302935 | ||
| T340 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T573 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S788 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y815 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T900 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1006 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
| K1196 | Methylation | score1 | PhosphoSitePlus | |||
| T1210 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1304 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1315 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1325 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S1503 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y1507 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K1564 | Methylation | score1 | PhosphoSitePlus | |||
| Y1615 | Phosphorylation | score1 | PhosphoSitePlus | |||
| C1707 | Methylation | score1 | IEDB | 31844290 | ||
| S1751 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T1955 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S2021 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K2152 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y2294 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S2295 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S2296 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K2390 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K2491 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K2505 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S338 | L338 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| Y735 | * | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S788 | N788 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] | |
| K1196 | N1196 | Biomuta | DOID:11054 / urinary bladder cancer [ icgc ] | |
| Y1304 | * | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| T1315 | A1315 | Biomuta | DOID:1319 / brain cancer [ cosmic, icgc ] | |
| Y1615 | H1615 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S2021 | N2021 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] | |
| S2296 | L2296 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| K2390 | R2390 | Biomuta | DOID:363 / uterine cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ] | |
| K2491 | M2491 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] |
DAG View