iPTMnet Report for Q9BYF1 (ACE2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BYF1 / ACE2_HUMAN
Protein Name Angiotensin-converting enzyme 2 precursor
Gene Name Name: ACE2
ORFNames:UNQ868/PRO1885;
Organism Homo sapiens (Human)

PRO ID PR:Q9BYF1
DAG View
PRO Name angiotensin-converting enzyme 2 (human)
Definition An angiotensin-converting enzyme 2 that is encoded in the genome of human.
Short Label hACE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BYF1 (ACE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
K26 Ubiquitination PhosphoSitePlus
K31 Methylation PhosphoSitePlus
S43 O-Glycosylation GlyGen 32841605
S44 O-Glycosylation GlyGen 32841605
N53 N-Glycosylation GlyGen   UniProt 14754895, 33135055, 32841605
Y83 Phosphorylation IEDB 35494241
N90 N-Glycosylation GlyGen   UniProt 15084671, 14754895, 33135055, ...32841605, 19901337
N103 N-Glycosylation GlyGen   UniProt 29741879, 14754895, 33135055, ...32841605
K112 Ubiquitination PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus
T129 O-Glycosylation GlyGen 32841605
T129 Phosphorylation PhosphoSitePlus
S155 O-Glycosylation GlyGen 32841605
S257 O-Glycosylation GlyGen 32841605
T294 O-Glycosylation GlyGen 32841605
N322 N-Glycosylation GlyGen   UniProt 14754895, 33135055, 32841605
T334 O-Glycosylation GlyGen 32841605
N432 N-Glycosylation GlyGen   UniProt 14754895, 33135055, 32841605
T496 O-Glycosylation GlyGen 32841605
Y516 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
N546 N-Glycosylation GlyGen   UniProt 19159218, 19901337, 32841605, ...14754895, 29741879, 33135055
S547 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
S602 O-Glycosylation GlyGen 32841605
S611 O-Glycosylation GlyGen 32841605
K625 Ubiquitination PhosphoSitePlus
R644 Methylation PhosphoSitePlus
R671 Methylation PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
S680 Phosphorylation PhosphoSitePlus   RLIMS-P 29570986
N690 N-Glycosylation GlyGen 29741879, 33135055
S692 Phosphorylation PhosphoSitePlus
T730 O-Glycosylation GlyGen 33135055
K770 Acetylation PhosphoSitePlus
K771 Acetylation PhosphoSitePlus
K773 Acetylation PhosphoSitePlus
S776 Phosphorylation PhosphoSitePlus
Y781 Phosphorylation PhosphoSitePlus   UniProt 33436497, 33436498
S783 Phosphorylation PhosphoSitePlus   UniProt 33436497, 33436498
S787 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K26 N26 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S43 R43 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S44 L44 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y83 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S128 I128 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T496 A496 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S545 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S602 Y602 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S602 F602 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K625 T625 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R644 Q644 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R671 Q671 Biomuta DOID:9256 / colorectal cancer [ cosmic ]