Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BYF1 / ACE2_HUMAN
Protein Name Angiotensin-converting enzyme 2 precursor
Gene Name Name: ACE2
ORFNames:UNQ868/PRO1885;
Organism Homo sapiens (Human)

PRO ID PR:Q9BYF1
DAG View
PRO Name angiotensin-converting enzyme 2 (human)
Definition An angiotensin-converting enzyme 2 that is encoded in the genome of human.
Short Label hACE2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BYF1 (ACE2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
N53 N-Glycosylation UniProt 14754895
N90 N-Glycosylation UniProt 15084671, 14754895
N103 N-Glycosylation UniProt 14754895
S128 Phosphorylation PhosphoSitePlus
T129 Phosphorylation PhosphoSitePlus
N322 N-Glycosylation UniProt 14754895
N432 N-Glycosylation UniProt 14754895
Y516 Phosphorylation PhosphoSitePlus
S545 Phosphorylation PhosphoSitePlus
N546 N-Glycosylation UniProt 14754895, 19159218
S547 Phosphorylation PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
K676 Ubiquitination PhosphoSitePlus
S692 Phosphorylation PhosphoSitePlus
K770 Acetylation PhosphoSitePlus
K771 Acetylation PhosphoSitePlus
K773 Acetylation PhosphoSitePlus
Y781 Phosphorylation PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S128 I128 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T129 N129 Biomuta DOID:3571 / liver cancer [ icgc ]
S545 * Biomuta DOID:1612 / breast cancer [ tcga ]
K625 T625 Biomuta DOID:9256 / colorectal cancer [ tcga ]