iPTMnet Report for Q9BY44 (EIF2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BY44 / EIF2A_HUMAN
Protein Name Eukaryotic translation initiation factor 2A
Gene Name Name: EIF2A
ORFNames:CDA02,MSTP004,MSTP089;
Organism Homo sapiens (Human)

PRO ID PR:Q9BY44
DAG View
PRO Name eukaryotic translation initiation factor 2A (human)
Definition A eukaryotic translation initiation factor 2A that is encoded in the genome of human.
Short Label hEIF2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BY44 (EIF2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S4 Phosphorylation PhosphoSitePlus
T5 Phosphorylation PhosphoSitePlus   UniProt 23186163
T9 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
S84 Phosphorylation IEDB   PhosphoSitePlus 35494241
T88 Phosphorylation PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T103 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
C119 Methylation IEDB 31844290
C119 S-Nitrosylation dbSNO 19483679
K121 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
Y251 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
Y349 Phosphorylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus
Y362 Phosphorylation PhosphoSitePlus
C366 Methylation IEDB 31844290
S395 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
Y446 Phosphorylation PhosphoSitePlus
K471 Methylation PhosphoSitePlus
K478 Methylation PhosphoSitePlus
S503 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 20068231, 18669648, 19690332, ...24275569
S506 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 17287340
T512 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S517 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512
S517 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T518 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18847512, 20068231
T518 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T522 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S524 Phosphorylation PhosphoSitePlus
S526 Phosphorylation PhosphoSitePlus   UniProt 23186163
S528 Phosphorylation PhosphoSitePlus
K535 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y349 Phosphorylation HPRD 18452278
Y392 Phosphorylation HPRD 20068231
S503 Phosphorylation HPRD 19651622, 18767875, 18669648, ...20068231, 18452278
S506 Phosphorylation HPRD 19413330, 17287340, 17081983, ...18767875, 20058876, 19664995, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 18212344
T512 Phosphorylation HPRD 17287340
S517 Phosphorylation HPRD 18669648, 20068231
T518 Phosphorylation HPRD 18669648, 19415658, 20068231
T522 Phosphorylation HPRD 17287340
S526 Phosphorylation HPRD 19651622, 20068231
S528 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T5 A5 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ]
T5 K5 Biomuta DOID:1324 / lung cancer [ cosmic ]
T9 I9 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T92 M92 Biomuta DOID:363 / uterine cancer [ cosmic ]
T92 S92 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K169 T169 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K216 N216 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y258 C258 Biomuta DOID:1319 / brain cancer [ cosmic ]
S517 N517 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S524 A524 Biomuta DOID:4159 / skin cancer [ cosmic ]