iPTMnet Report for Q9BXW9 (FANCD2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BXW9 / FACD2_HUMAN
Protein Name Fanconi anemia group D2 protein
Gene Name Name: FANCD2
Synonyms:FACD;
Organism Homo sapiens (Human)

PRO ID PR:Q9BXW9
DAG View
PRO Name Fanconi anemia group D2 protein (human)
Definition A Fanconi anemia group D2 protein that is encoded in the genome of human.
Short Label hFANCD2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BXW9 (FANCD2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S15 Phosphorylation PhosphoSitePlus
K33 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
S126 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S167 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S178 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K181 Ubiquitination PhosphoSitePlus
K190 Ubiquitination PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S222 Phosphorylation Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12447395, 12086603, 12767353, ...21466974
S251 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
C310 Methylation IEDB 31844290
S319 Phosphorylation PhosphoSitePlus
K322 Ubiquitination PhosphoSitePlus
S331 Phosphorylation O14757 (CHEK1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 19861535
K358 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
Y458 Phosphorylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus   UniProt 20603016, 19111657, 20603015, ...20603073, 11239454
K569 Ubiquitination PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
S592 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 17525332, 23186163
S594 Phosphorylation PhosphoSitePlus   UniProt 20068231
T596 Phosphorylation Q13535 (ATR) phospho.ELM   PhosphoSitePlus 17525332, 16943440
T608 Phosphorylation Q13535 (ATR) PhosphoSitePlus 16943440
Y684 Phosphorylation PhosphoSitePlus
T691 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 16943440
S705 Phosphorylation PhosphoSitePlus
S717 Phosphorylation Q13535 (ATR) , Q13315 (ATM) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 16943440, 15302935, ...20068231
K723 Ubiquitination PhosphoSitePlus
K878 Ubiquitination PhosphoSitePlus
S882 Phosphorylation PhosphoSitePlus
T884 Phosphorylation PhosphoSitePlus
S886 Phosphorylation PhosphoSitePlus
K889 Ubiquitination PhosphoSitePlus
S891 Phosphorylation PhosphoSitePlus
T896 Phosphorylation PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
K905 Ubiquitination PhosphoSitePlus
K913 Ubiquitination PhosphoSitePlus
S978 Phosphorylation PhosphoSitePlus
T981 Phosphorylation PhosphoSitePlus
K992 Methylation PhosphoSitePlus
K992 Ubiquitination PhosphoSitePlus
C1015 Methylation IEDB 31844290
C1061 Methylation IEDB 31844290
K1154 Ubiquitination PhosphoSitePlus
S1157 Phosphorylation PhosphoSitePlus
K1172 Acetylation PhosphoSitePlus
K1198 Acetylation PhosphoSitePlus
S1214 Phosphorylation PhosphoSitePlus
K1216 Ubiquitination PhosphoSitePlus
T1225 O-Glycosylation GlyGen 30379171
T1227 O-Glycosylation GlyGen 30379171
K1248 Ubiquitination PhosphoSitePlus
T1253 Phosphorylation PhosphoSitePlus
S1257 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus   UniProt 12086603, 23186163
K1346 Ubiquitination PhosphoSitePlus
K1361 Ubiquitination PhosphoSitePlus
K1362 Ubiquitination PhosphoSitePlus
T1363 Phosphorylation PhosphoSitePlus
K1372 Ubiquitination PhosphoSitePlus
K1390 Ubiquitination PhosphoSitePlus
S1401 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 12086603
S1404 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor   UniProt 12086603
S1407 Phosphorylation Q13315 (ATM) PhosphoSitePlus   Signor 12086603
T1408 Phosphorylation PhosphoSitePlus
S1412 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163, 15302935, ...18669648, 20068231
S1418 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
S1423 Phosphorylation PhosphoSitePlus   UniProt 20068231
T1426 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1435 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 18669648, 20068231
S167 Phosphorylation HPRD 17525332
S178 Phosphorylation HPRD 17525332
S222 Phosphorylation Q13315 (ATM) HPRD 12086603
S330 Phosphorylation HPRD 18691976
S592 Phosphorylation HPRD 18691976, 15302935, 18077418, ...19664994, 19007248, 19691289, 20068231
S594 Phosphorylation HPRD 19691289, 20068231
T596 Phosphorylation HPRD 17525332, 18077418
T691 Phosphorylation HPRD 18452278
S717 Phosphorylation HPRD 15302935, 20068231
S720 Phosphorylation HPRD 20068231
S1257 Phosphorylation Q13315 (ATM) HPRD 12086603, 20068231
S1401 Phosphorylation HPRD 18452278
S1412 Phosphorylation HPRD 19413330, 15302935, 19664994, ...18452278, 19651622, 18669648, 20068231
S1418 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 18669648, 20068231
S167 Phosphorylation HPRD 17525332
S178 Phosphorylation HPRD 17525332
S222 Phosphorylation Q9BS79 (MRE11A) , Q13315 (ATM) HPRD 12447395, 12086603
S330 Phosphorylation HPRD 18691976
S592 Phosphorylation HPRD 18691976, 15302935, 18077418, ...19664994, 19007248, 19691289, 20068231
S594 Phosphorylation HPRD 19691289, 20068231
T596 Phosphorylation HPRD 17525332, 18077418
T691 Phosphorylation HPRD 18452278
S717 Phosphorylation HPRD 15302935, 20068231
S720 Phosphorylation HPRD 20068231
S1257 Phosphorylation Q13315 (ATM) HPRD 12086603, 20068231
S1401 Phosphorylation HPRD 18452278
S1412 Phosphorylation HPRD 19413330, 15302935, 19664994, ...18452278, 19651622, 18669648, 20068231
S1418 Phosphorylation HPRD 17525332
S1423 Phosphorylation HPRD 20068231
T1426 Phosphorylation HPRD 20068231
S1435 Phosphorylation HPRD 19651622, 19691289, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 R15 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S15 I15 Biomuta DOID:1324 / lung cancer [ cosmic ]
K53 Q53 Biomuta DOID:1324 / lung cancer [ cosmic ]
S126 I126 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K156 T156 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S271 L271 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
K358 E358 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S590 R590 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S720 L720 Biomuta DOID:4159 / skin cancer [ cosmic ]
S882 C882 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S882 F882 Biomuta DOID:1324 / lung cancer [ cosmic ]
S886 L886 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S891 L891 Biomuta DOID:4159 / skin cancer [ cosmic ]
T896 M896 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K913 N913 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T981 I981 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ]
S1157 F1157 Biomuta DOID:1612 / breast cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S1157 A1157 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S1257 L1257 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ]
S1257 W1257 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1257 A1257 Biomuta DOID:1612 / breast cancer [ icgc ]
S1404 F1404 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic, cosmic ]
S1412 N1412 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1412 G1412 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1435 T1435 Biomuta DOID:1612 / breast cancer [ cosmic ]