iPTMnet Report for Q9BXS4 (TMEM59)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BXS4 / TMM59_HUMAN
Protein Name Transmembrane protein 59 precursor
Gene Name Name: TMEM59
Synonyms:C1orf8;ORFNames:HSPC001,UNQ169/PRO195;
Organism Homo sapiens (Human)

PRO ID PR:Q9BXS4
DAG View
PRO Name transmembrane protein 59 (human)
Definition A transmembrane protein 59 that is encoded in the genome of human.
Short Label hTMEM59
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BXS4 (TMEM59) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K63 Ubiquitination PhosphoSitePlus
S78 O-Glycosylation GlyGen 34105348
N90 N-Glycosylation GlyGen   UniProt 20427278
S133 Phosphorylation HPRD   PhosphoSitePlus 20068231
K183 Ubiquitination PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
C233 Methylation IEDB 31844290
Y277 Phosphorylation PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
T314 O-Glycosylation GlyGen 25813380
K315 Ubiquitination PhosphoSitePlus
S321 Phosphorylation HPRD   PhosphoSitePlus 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K63 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K315 Q315 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K315 N315 Biomuta DOID:3571 / liver cancer [ cosmic ]
S321 F321 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]