Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BX66 / SRBS1_HUMAN
Protein Name Sorbin and SH3 domain-containing protein 1
Gene Name Name: SORBS1
Synonyms:KIAA0894,KIAA1296,SH3D5;
Organism Homo sapiens (Human)

PRO ID PR:Q9BX66
DAG View
PRO Name sorbin and SH3 domain-containing protein 1 (human)
Definition A sorbin and SH3 domain-containing protein 1 that is encoded in the genome of human.
Short Label hSORBS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BX66 (SORBS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T72 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
Y79 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T82 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S84 Phosphorylation PhosphoSitePlus
S85 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
S86 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S89 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 19664994, ...19664995, 18669648
S127 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S152 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus   UniProt 24275569
S259 Phosphorylation PhosphoSitePlus   UniProt 24275569
T264 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S281 Phosphorylation HPRD 20166139, 18669648, 19664995
S299 Phosphorylation HPRD 20068231
S303 Phosphorylation HPRD 18669648
R323 Methylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus   UniProt 24275569
T344 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20166139, 18669648
T349 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20166139, 18669648
S350 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 19664995, 18669648, ...24275569, 20166139
S369 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
S431 Phosphorylation HPRD 20068231
Y460 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
T470 Phosphorylation PhosphoSitePlus
S472 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648
S475 Phosphorylation PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y485 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
T497 Phosphorylation PhosphoSitePlus
S509 Phosphorylation HPRD   PhosphoSitePlus 20068231
S534 Phosphorylation PhosphoSitePlus
Y536 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus 19891780
Y538 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus   UniProt 24275569
S593 Phosphorylation HPRD 20068231
S609 Phosphorylation PhosphoSitePlus
S640 Phosphorylation phospho.ELM 18669648
Y654 Phosphorylation P00519 (ABL1) neXtProt 19891780
S655 Phosphorylation HPRD 19664995
S665 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 20166139, 18669648, 23186163, ...24275569
T673 Phosphorylation PhosphoSitePlus
S684 Phosphorylation HPRD   PhosphoSitePlus 20068231
S697 Phosphorylation PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus   UniProt 24275569
S711 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
Y722 Phosphorylation PhosphoSitePlus
S725 Phosphorylation HPRD 20068231
T726 Phosphorylation PhosphoSitePlus
S791 Phosphorylation PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
T862 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
T912 Phosphorylation HPRD 20068231
T921 Phosphorylation HPRD 20068231
Y937 Phosphorylation PhosphoSitePlus   UniProt 24275569
S943 Phosphorylation HPRD   PhosphoSitePlus 20068231
S944 Phosphorylation phospho.ELM 18669648
S945 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19664995, 20068231
S947 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S953 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1004 Phosphorylation PhosphoSitePlus
T1018 Phosphorylation PhosphoSitePlus
T1045 Phosphorylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
Y1127 Phosphorylation PhosphoSitePlus
K1130 Acetylation PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
S1183 Phosphorylation PhosphoSitePlus
T1193 Phosphorylation PhosphoSitePlus
T1223 Phosphorylation PhosphoSitePlus
Y1240 Phosphorylation P00519 (ABL1) neXtProt 19891780
Site PTM Type PTM Enzyme Score Source PMID
S379 Phosphorylation PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
Y490 Phosphorylation PhosphoSitePlus
Y492 Phosphorylation PhosphoSitePlus
S725 Phosphorylation PhosphoSitePlus
S726 Phosphorylation PhosphoSitePlus
S727 Phosphorylation PhosphoSitePlus
S731 Phosphorylation PhosphoSitePlus
T733 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S411 Phosphorylation PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
T1180 Phosphorylation PhosphoSitePlus
Y1186 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y79 Phosphorylation phospho.ELM 18669648
T82 Phosphorylation phospho.ELM 18669648
S85 Phosphorylation phospho.ELM 18669648
S86 Phosphorylation phospho.ELM 18669648
S89 Phosphorylation phospho.ELM 18669648
S212 Phosphorylation phospho.ELM 18669648
S342 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
S804 Phosphorylation PhosphoSitePlus
Y825 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S105 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S593 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
T601 Phosphorylation PhosphoSitePlus
S603 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S137 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
T763 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S260 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y79 * Biomuta DOID:3571 / liver cancer [ icgc ]
S84 N84 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T237 A237 Biomuta DOID:3571 / liver cancer [ icgc ]
S259 L259 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R323 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S332 L332 Biomuta DOID:1612 / breast cancer [ tcga ]
S369 R369 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S369 G369 Biomuta DOID:1612 / breast cancer [ tcga ]
S431 F431 Biomuta DOID:363 / uterine cancer [ tcga ]
S465 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S475 Y475 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S481 T481 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S552 N552 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S552 R552 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S593 Y593 Biomuta DOID:363 / uterine cancer [ tcga ]
S655 Y655 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
S655 C655 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S713 L713 Biomuta DOID:1909 / melanoma [ tcga ] DOID:3571 / liver cancer [ icgc ]
T726 A726 Biomuta DOID:363 / uterine cancer [ tcga ]
S791 Y791 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T912 K912 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
T1004 I1004 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T1018 N1018 Biomuta DOID:3571 / liver cancer [ icgc ]
T1045 I1045 Biomuta DOID:1909 / melanoma [ tcga ]
K1130 T1130 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S1167 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
Y1240 H1240 Biomuta DOID:0070003 / blastoma [ cosmic ]
Y1240 F1240 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]