iPTMnet Report for Q9BX66 (SORBS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BX66 / SRBS1_HUMAN
Protein Name Sorbin and SH3 domain-containing protein 1
Gene Name Name: SORBS1
Synonyms:KIAA0894,KIAA1296,SH3D5;
Organism Homo sapiens (Human)

PRO ID PR:Q9BX66
DAG View
PRO Name sorbin and SH3 domain-containing protein 1 (human)
Definition A sorbin and SH3 domain-containing protein 1 that is encoded in the genome of human.
Short Label hSORBS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BX66 (SORBS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T72 Phosphorylation PhosphoSitePlus
S76 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
Y79 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T82 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S84 Phosphorylation PhosphoSitePlus
S85 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S86 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S89 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
E105 Phosphorylation UniProt 24275569
L114 Phosphorylation UniProt 24275569
S127 Phosphorylation PhosphoSitePlus
V137 Phosphorylation UniProt 24275569
S146 Phosphorylation PhosphoSitePlus   UniProt 24275569
S152 Phosphorylation PhosphoSitePlus
T181 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus   UniProt 24275569
S259 Phosphorylation PhosphoSitePlus   UniProt 24275569
T264 Phosphorylation PhosphoSitePlus
S268 Phosphorylation PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S299 Phosphorylation HPRD 20068231
R323 Methylation PhosphoSitePlus
S325 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
S332 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus   UniProt 24275569
T344 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
E346 Phosphorylation UniProt 18669648
T349 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S350 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S369 Phosphorylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
N387 Phosphorylation UniProt 18669648
S452 Phosphorylation UniProt 24275569
Y460 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
D469 Phosphorylation UniProt 18669648
T470 Phosphorylation PhosphoSitePlus
S472 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S475 Phosphorylation PhosphoSitePlus
R478 Phosphorylation UniProt 18669648
S479 O-Glycosylation GlyGen 30379171, 28657654
S479 Phosphorylation PhosphoSitePlus
S481 Phosphorylation PhosphoSitePlus   UniProt 21406692
Y485 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
T497 Phosphorylation PhosphoSitePlus
S509 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
Y536 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus 19891780
Y538 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus   UniProt 24275569
N603 Phosphorylation UniProt 18669648
S609 Phosphorylation PhosphoSitePlus
S640 Phosphorylation phospho.ELM 18669648
Y654 Phosphorylation P00519 (ABL1) neXtProt 19891780
S655 Phosphorylation HPRD 19664995
S665 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
T673 Phosphorylation PhosphoSitePlus
S684 Phosphorylation PhosphoSitePlus
S697 Phosphorylation PhosphoSitePlus
K700 Phosphorylation UniProt 18669648
S703 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
S707 Phosphorylation PhosphoSitePlus
T708 O-Glycosylation GlyGen 30379171, 28657654
T708 Phosphorylation PhosphoSitePlus   UniProt 24275569
S711 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
Y722 Phosphorylation PhosphoSitePlus
T726 Phosphorylation PhosphoSitePlus
I730 Phosphorylation UniProt 18669648
D735 Phosphorylation UniProt 18669648
I765 Phosphorylation UniProt 18669648
S791 Phosphorylation PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
T862 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 24275569
V923 Phosphorylation UniProt 18669648
Y937 Phosphorylation PhosphoSitePlus   UniProt 24275569
S943 O-Glycosylation GlyGen 30379171, 28657654
S943 Phosphorylation PhosphoSitePlus
S944 Phosphorylation phospho.ELM 18669648
S945 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S947 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S953 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1004 Phosphorylation PhosphoSitePlus
T1018 Phosphorylation PhosphoSitePlus
T1045 Phosphorylation PhosphoSitePlus
S1048 O-Glycosylation GlyGen 30379171, 28657654
S1051 Phosphorylation PhosphoSitePlus
S1124 Phosphorylation PhosphoSitePlus
Y1127 Phosphorylation PhosphoSitePlus
K1130 Acetylation PhosphoSitePlus
S1167 Phosphorylation PhosphoSitePlus
S1183 Phosphorylation PhosphoSitePlus
T1193 Phosphorylation PhosphoSitePlus
Q1213 Phosphorylation UniProt 18669648
T1223 Phosphorylation PhosphoSitePlus
Y1240 Phosphorylation P00519 (ABL1) neXtProt 19891780
Site PTM Type PTM Enzyme Score Source PMID
Y79 Phosphorylation HPRD 18669648
T82 Phosphorylation HPRD 18669648
S85 Phosphorylation HPRD 18669648
S86 Phosphorylation HPRD 18669648
S89 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995
T344 Phosphorylation HPRD 20166139, 18669648
T349 Phosphorylation HPRD 20166139, 18669648
S350 Phosphorylation HPRD 20166139, 18669648, 19664995
S472 Phosphorylation HPRD 18669648
S509 Phosphorylation HPRD 20068231
S665 Phosphorylation HPRD 20166139, 18669648
S684 Phosphorylation HPRD 20068231
T862 Phosphorylation HPRD 18669648
T912 Phosphorylation HPRD 20068231
T921 Phosphorylation HPRD 20068231
S943 Phosphorylation HPRD 20068231
S945 Phosphorylation HPRD 18669648, 19664995, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y47 Phosphorylation HPRD 18669648
T50 Phosphorylation HPRD 18669648
S53 Phosphorylation HPRD 18669648
S54 Phosphorylation HPRD 18669648
S57 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995
T312 Phosphorylation HPRD 20166139, 18669648
T317 Phosphorylation HPRD 20166139, 18669648
S318 Phosphorylation HPRD 20166139, 18669648, 19664995
S379 Phosphorylation PhosphoSitePlus
Y382 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
S394 Phosphorylation HPRD 18669648
S431 Phosphorylation HPRD 20068231
S478 Phosphorylation HPRD   PhosphoSitePlus 18669648
T480 Phosphorylation PhosphoSitePlus
Y490 Phosphorylation PhosphoSitePlus
Y492 Phosphorylation PhosphoSitePlus
S503 Phosphorylation HPRD 20166139, 18669648
S522 Phosphorylation HPRD 20068231
T644 Phosphorylation HPRD 18669648
T694 Phosphorylation HPRD 20068231
T703 Phosphorylation HPRD 20068231
S725 Phosphorylation HPRD   PhosphoSitePlus 20068231
S726 Phosphorylation PhosphoSitePlus
S727 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19664995, 20068231
S731 Phosphorylation HPRD   PhosphoSitePlus 19664995
T733 Phosphorylation PhosphoSitePlus
S735 Phosphorylation HPRD   PhosphoSitePlus 20166139, 18669648, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S411 Phosphorylation PhosphoSitePlus
Y414 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
T1180 Phosphorylation PhosphoSitePlus
Y1186 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y79 Phosphorylation HPRD 18669648
T82 Phosphorylation HPRD 18669648
S85 Phosphorylation HPRD 18669648
S86 Phosphorylation HPRD 18669648
S89 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995
T344 Phosphorylation HPRD 20166139, 18669648
T349 Phosphorylation HPRD 20166139, 18669648
S350 Phosphorylation HPRD 20166139, 18669648, 19664995
S494 Phosphorylation HPRD 18669648
S531 Phosphorylation HPRD 20068231
S687 Phosphorylation HPRD 20166139, 18669648
S706 Phosphorylation HPRD 20068231
T884 Phosphorylation HPRD 18669648
T934 Phosphorylation HPRD 20068231
T943 Phosphorylation HPRD 20068231
S965 Phosphorylation HPRD 20068231
S967 Phosphorylation HPRD 18669648, 19664995, 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y79 Phosphorylation HPRD   phospho.ELM 18669648
T82 Phosphorylation HPRD   phospho.ELM 18669648
S85 Phosphorylation HPRD   phospho.ELM 18669648
S86 Phosphorylation HPRD   phospho.ELM 18669648
S89 Phosphorylation HPRD   phospho.ELM 19413330, 18669648, 19664994, ...19664995
S212 Phosphorylation phospho.ELM 18669648
T275 Phosphorylation HPRD 20166139, 18669648
T280 Phosphorylation HPRD 20166139, 18669648
S281 Phosphorylation HPRD 20166139, 18669648, 19664995
S342 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
S350 Phosphorylation PhosphoSitePlus
S357 Phosphorylation HPRD 18669648
S394 Phosphorylation HPRD 20068231
S516 Phosphorylation HPRD 20166139, 18669648
S535 Phosphorylation HPRD 20068231
T713 Phosphorylation HPRD 18669648
T763 Phosphorylation HPRD 20068231
T772 Phosphorylation HPRD 20068231
S794 Phosphorylation HPRD 20068231
S795 Phosphorylation HPRD 18669648
S796 Phosphorylation HPRD 18669648, 19664995, 20068231
S798 Phosphorylation HPRD 18669648
S804 Phosphorylation HPRD   PhosphoSitePlus 18669648
Y825 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y47 Phosphorylation HPRD 18669648
T50 Phosphorylation HPRD 18669648
S53 Phosphorylation HPRD 18669648
S54 Phosphorylation HPRD 18669648
S57 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995
S105 Phosphorylation PhosphoSitePlus
T180 Phosphorylation HPRD 20166139, 18669648
T185 Phosphorylation HPRD 20166139, 18669648
S186 Phosphorylation HPRD 20166139, 18669648, 19664995
S247 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
S262 Phosphorylation HPRD 18669648
S299 Phosphorylation HPRD 20068231
S346 Phosphorylation HPRD   PhosphoSitePlus 18669648
S371 Phosphorylation HPRD 20166139, 18669648
S390 Phosphorylation HPRD 20068231
T512 Phosphorylation HPRD 18669648
T562 Phosphorylation HPRD 20068231
T571 Phosphorylation HPRD 20068231
S593 Phosphorylation HPRD   PhosphoSitePlus 20068231
S594 Phosphorylation PhosphoSitePlus
S595 Phosphorylation HPRD   PhosphoSitePlus 18669648, 19664995, 20068231
S599 Phosphorylation HPRD   PhosphoSitePlus 19664995
T601 Phosphorylation PhosphoSitePlus
S603 Phosphorylation HPRD   PhosphoSitePlus 20166139, 18669648, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S137 Phosphorylation PhosphoSitePlus
S452 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
T763 Phosphorylation PhosphoSitePlus
S765 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S260 Phosphorylation PhosphoSitePlus
S730 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y79 Phosphorylation HPRD 18669648
T82 Phosphorylation HPRD 18669648
S85 Phosphorylation HPRD 18669648
S86 Phosphorylation HPRD 18669648
S89 Phosphorylation HPRD 19413330, 18669648, 19664994, ...19664995
T221 Phosphorylation HPRD 20166139, 18669648
T226 Phosphorylation HPRD 20166139, 18669648
S227 Phosphorylation HPRD 20166139, 18669648, 19664995
S303 Phosphorylation HPRD 18669648
S340 Phosphorylation HPRD 20068231
S387 Phosphorylation HPRD 18669648
S412 Phosphorylation HPRD 20166139, 18669648
S431 Phosphorylation HPRD 20068231
T609 Phosphorylation HPRD 18669648
T659 Phosphorylation HPRD 20068231
T668 Phosphorylation HPRD 20068231
S690 Phosphorylation HPRD 20068231
S692 Phosphorylation HPRD 18669648, 19664995, 20068231
S696 Phosphorylation HPRD 19664995
S700 Phosphorylation HPRD 20166139, 18669648, 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S84 N84 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
E105 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
E105 Q105 Biomuta DOID:1324 / lung cancer [ cosmic ]
E105 K105 Biomuta DOID:4159 / skin cancer [ cosmic ]
T237 A237 Biomuta [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S240 F240 Biomuta DOID:4159 / skin cancer [ cosmic ]
S255 L255 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S255 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S259 L259 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T264 M264 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S268 L268 Biomuta DOID:4159 / skin cancer [ cosmic ]
R323 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S332 L332 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
E346 K346 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S350 L350 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S350 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S369 R369 Biomuta DOID:3571 / liver cancer [ cosmic ]
S369 G369 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S387 L387 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S387 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S419 L419 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S419 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S465 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S465 L465 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
D469 Y469 Biomuta DOID:1324 / lung cancer [ cosmic ]
S475 Y475 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R478 C478 Biomuta DOID:4159 / skin cancer [ cosmic ]
S481 T481 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S552 N552 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S552 R552 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T562 K562 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S593 F593 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S609 G609 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S655 Y655 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S655 C655 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T659 K659 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S690 F690 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T694 K694 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S703 F703 Biomuta DOID:4159 / skin cancer [ cosmic ]
S713 L713 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ]
S725 F725 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T726 A726 Biomuta DOID:363 / uterine cancer [ icgc ]
T726 M726 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
T763 K763 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S794 F794 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T912 K912 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
V923 M923 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
T934 K934 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S943 F943 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S965 F965 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1004 I1004 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
T1045 I1045 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1130 T1130 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1167 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S1183 N1183 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1183 G1183 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1240 H1240 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y1240 F1240 Biomuta DOID:3571 / liver cancer [ cosmic ]