Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BWD1 / THIC_HUMAN
Protein Name Acetyl-CoA acetyltransferase, cytosolic
Gene Name Name: ACAT2
Synonyms:ACTL;
Organism Homo sapiens (Human)

PRO ID PR:Q9BWD1
DAG View
PRO Name acetyl-CoA acetyltransferase, cytosolic (human)
Definition An acetyl-CoA acetyltransferase, cytosolic that is encoded in the genome of human.
Short Label hACAT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BWD1 (ACAT2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378, 22223895
K39 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
R188 Methylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K200 Acetylation PhosphoSitePlus   UniProt 19608861
K200 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K233 Acetylation PhosphoSitePlus   UniProt 19608861
K233 Ubiquitination PhosphoSitePlus
K235 Acetylation PhosphoSitePlus   UniProt 19608861
K235 Ubiquitination PhosphoSitePlus
T240 O-Glycosylation GlyGen 28510447, 29351928
K265 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K211 R211 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K341 R341 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]