iPTMnet Report for Q9BW92 (TARS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BW92 / SYTM_HUMAN
Protein Name Threonine--tRNA ligase, mitochondrial precursor
Gene Name Name: TARS2
Synonyms:TARSL1;
Organism Homo sapiens (Human)

PRO ID PR:Q9BW92
DAG View
PRO Name threonine--tRNA ligase, mitochondrial (human)
Definition A threonine--tRNA ligase, mitochondrial that is encoded in the genome of human.
Short Label hTARS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BW92 (TARS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S52 Phosphorylation PhosphoSitePlus   UniProt 21406692
K56 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
K352 Ubiquitination PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
R429 Methylation PhosphoSitePlus
C463 Methylation IEDB 31844290
K520 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
Y536 Phosphorylation PhosphoSitePlus
K572 Ubiquitination PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K62 N62 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K169 R169 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y332 C332 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R429 Q429 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y536 C536 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]