iPTMnet Report for Q9BV44 (THUMPD3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BV44 / THUM3_HUMAN
Protein Name tRNA (guanine(6)-N2)-methyltransferase THUMP3
Gene Name Name: THUMPD3
Organism Homo sapiens (Human)

PRO ID PR:Q9BV44
DAG View
PRO Name tRNA (guanine(6)-N2)-methyltransferase THUMP3 (human)
Definition A tRNA (guanine(6)-N2)-methyltransferase THUMP3 that is encoded in the genome of human.
Short Label hTHUMPD3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BV44 (THUMPD3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K65 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
S138 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
Y187 Phosphorylation PhosphoSitePlus
Y188 Phosphorylation PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
S207 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
K258 Ubiquitination PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
R313 Methylation PhosphoSitePlus
K369 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
K417 Acetylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K115 N115 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K194 N194 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S207 P207 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S216 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K449 E449 Biomuta DOID:10283 / prostate cancer [ cosmic ]
T501 A501 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]