iPTMnet Report for Q9BUR4 (WRAP53)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BUR4 / TCAB1_HUMAN
Protein Name Telomerase Cajal body protein 1
Gene Name Name: WRAP53
Synonyms:TCAB1;
Organism Homo sapiens (Human)

PRO ID PR:Q9BUR4
DAG View
PRO Name telomerase Cajal body protein 1 (human)
Definition A telomerase Cajal body protein 1 that is encoded in the genome of human.
Short Label hWRAP53
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BUR4 (WRAP53) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S26 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S30 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S54 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18220336, ...18452278, 19651622, 18669648, 24275569, 20068231
S64 Phosphorylation Q13315 (ATM) HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17525332, 23186163, 20068231, ...27715493
S74 Phosphorylation HPRD 20068231
T77 Phosphorylation PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
S85 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18452278, 19651622, ...18669648, 24275569, 19690332, 20068231
S87 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 20068231, ...18452278
S90 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...15302935, 19664994, 18452278, 19651622, 18669648, 24275569, 17693683, 19690332, 20068231, 17081983
S99 Phosphorylation PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
S103 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18669648, 18452278
S112 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 19690332, ...18452278
S114 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 19690332, ...18452278
S133 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
Y211 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
C312 Methylation IEDB 31844290
K321 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
T489 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18452278, 17322306, 18669648, ...19690332, 20068231
S491 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 18491316, ...23186163, 17081983, 18220336, 19664994, 15302935, 18452278, 19651622, 18669648, 19690332, 20166139, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S26 P26 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S74 Y74 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S87 G87 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S103 N103 Biomuta DOID:363 / uterine cancer [ icgc ]
S112 N112 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]