iPTMnet Report for Q9BTU6 (PI4K2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BTU6 / P4K2A_HUMAN
Protein Name Phosphatidylinositol 4-kinase type 2-alpha
Gene Name Name: PI4K2A
Organism Homo sapiens (Human)

PRO ID PR:Q9BTU6
DAG View
PRO Name phosphatidylinositol 4-kinase type 2-alpha (human)
Definition A phosphatidylinositol 4-kinase type 2-alpha that is encoded in the genome of human.
Short Label hPI4K2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BTU6 (PI4K2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378, 20068231, 25944712
S5 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 23186163, 17081983, ...19651622, 20068231
S9 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 23186163, 17081983, ...19651622, 20068231
Y18 Phosphorylation PhosphoSitePlus
T19 Phosphorylation PhosphoSitePlus
S44 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 17081983, 19651622, ...18669648, 24275569, 18707149, 20068231
S47 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 21406692, 23186163, ...17081983, 18767875, 19664994, 18578522, 19415658, 19651622, 18669648, 24275569, 18707149, 20166139, 19690332, 20068231
S51 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18578522, 23186163, ...17081983, 18767875, 19664994, 21406692, 19690332, 19651622, 18669648, 24275569, 18707149, 20166139, 19415658, 20068231
Y138 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
K240 Methylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K243 Methylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
K336 Ubiquitination PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K373 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
T431 Phosphorylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
S460 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 20166139, 18669648, 19664995
S461 Phosphorylation HPRD   PhosphoSitePlus 19413330, 18578522
S462 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18767875, 15302935, 19664995, ...18452278, 19664994, 18669648, 20166139
S464 Phosphorylation HPRD   PhosphoSitePlus 19664995
Y465 Phosphorylation PhosphoSitePlus
T466 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
K473 Ubiquitination PhosphoSitePlus


Q9BTU6 (PI4K2A) as PTM Enzyme



Substrate Site Score Source PMID
Q9HAW4 (CLSPN) S984 Signor 18082599


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 N5 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K336 R336 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K354 N354 Biomuta DOID:1319 / brain cancer [ icgc ]
K435 N435 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S461 F461 Biomuta DOID:1324 / lung cancer [ cosmic ]