iPTMnet Report for Q9BTL3 (RAMAC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BTL3 / RAMAC_HUMAN
Protein Name RNA guanine-N7 methyltransferase activating subunit
Gene Name Name: RAMAC
Synonyms:C15orf18,FAM103A1,RAMMET;
Organism Homo sapiens (Human)

PRO ID PR:Q9BTL3
DAG View
PRO Name RNA guanine-N7 methyltransferase activating subunit (human)
Definition An RNA guanine-N7 methyltransferase activating subunit that is encoded in the genome of human.
Short Label hRAMAC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BTL3 (RAMAC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Acetylation UniProt 19413330, 22814378
S17 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
Y29 Phosphorylation PhosphoSitePlus
S36 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18452278, ...18669648, 19690332, 20068231
R46 Methylation PhosphoSitePlus
R54 Methylation PhosphoSitePlus
R57 Methylation PhosphoSitePlus
R62 Methylation PhosphoSitePlus
R65 Methylation PhosphoSitePlus
R67 Methylation PhosphoSitePlus
R70 Methylation PhosphoSitePlus
R78 Methylation PhosphoSitePlus
S79 Phosphorylation PhosphoSitePlus
R85 Methylation PhosphoSitePlus   UniProt 24129315
S86 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y104 Phosphorylation PhosphoSitePlus
R112 Methylation IEDB   PhosphoSitePlus 27503676


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S17 T17 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K24 M24 Biomuta DOID:1324 / lung cancer [ cosmic ]
R54 K54 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R57 Q57 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R57 W57 Biomuta DOID:363 / uterine cancer [ icgc ]
R65 I65 Biomuta DOID:363 / uterine cancer [ icgc ]
R65 T65 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R67 S67 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R70 T70 Biomuta DOID:1612 / breast cancer [ cosmic ]
R85 Q85 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R85 * Biomuta DOID:4159 / skin cancer [ cosmic ]