Protein Information

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UniProt AC / UniProt ID Q9BTC0 / DIDO1_HUMAN
Protein Name Death-inducer obliterator 1
Gene Name Name: DIDO1
Synonyms:C20orf158,DATF1,KIAA0333;
Organism Homo sapiens (Human)

PRO ID PR:Q9BTC0
DAG View
PRO Name death-inducer obliterator 1 (human)
Definition A death-inducer obliterator 1 that is encoded in the genome of human.
Short Label hDIDO1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BTC0 (DIDO1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S8 Phosphorylation PhosphoSitePlus
K21 Acetylation PhosphoSitePlus
T32 Phosphorylation PhosphoSitePlus
T33 Phosphorylation PhosphoSitePlus
S60 Phosphorylation PhosphoSitePlus   UniProt 23186163
S88 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
C102 S-Nitrosylation dbSNO 26338901
T109 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
T151 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 20068231
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231, ...17081983
S154 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 17081983, ...20068231
S156 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S203 Phosphorylation PhosphoSitePlus
K247 Sumoylation PhosphoSitePlus
C350 S-Nitrosylation dbSNO 26338901
K359 Ubiquitination PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
K383 Ubiquitination PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
S465 Phosphorylation PhosphoSitePlus
K474 Acetylation PhosphoSitePlus
S489 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
S501 Phosphorylation PhosphoSitePlus
T502 Phosphorylation PhosphoSitePlus
S504 Phosphorylation PhosphoSitePlus
S507 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
T519 Phosphorylation PhosphoSitePlus
S523 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 23186163
S525 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
S572 Phosphorylation PhosphoSitePlus
T603 Phosphorylation PhosphoSitePlus
S606 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
S609 Phosphorylation PhosphoSitePlus
K626 Acetylation PhosphoSitePlus
K627 Acetylation PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
S660 Phosphorylation PhosphoSitePlus
S677 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
K679 Ubiquitination PhosphoSitePlus
Y721 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
K753 Ubiquitination PhosphoSitePlus
S781 Phosphorylation PhosphoSitePlus
S805 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18669648, 19690332, 20068231
S809 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 19690332, 20068231
S811 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S817 Phosphorylation phospho.ELM 18669648
S862 Phosphorylation PhosphoSitePlus
S898 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...17081983
S918 Phosphorylation PhosphoSitePlus
S920 Phosphorylation PhosphoSitePlus
S947 Phosphorylation PhosphoSitePlus
T1004 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
S1005 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
S1011 Phosphorylation PhosphoSitePlus
K1015 Acetylation PhosphoSitePlus
K1015 Ubiquitination PhosphoSitePlus
S1017 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1018 Phosphorylation PhosphoSitePlus
S1019 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1030 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S1034 Phosphorylation PhosphoSitePlus
T1035 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1036 Phosphorylation PhosphoSitePlus
R1039 Methylation PhosphoSitePlus
S1040 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 15302935, 20068231
K1072 Ubiquitination PhosphoSitePlus
K1100 Ubiquitination PhosphoSitePlus
K1108 Ubiquitination PhosphoSitePlus
S1205 Phosphorylation PhosphoSitePlus
Y1228 Phosphorylation PhosphoSitePlus
S1237 Phosphorylation PhosphoSitePlus
S1242 Phosphorylation PhosphoSitePlus
Y1244 Phosphorylation PhosphoSitePlus   UniProt 24275569
S1248 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1254 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1255 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1256 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1260 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692
S1277 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
S1285 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
S1285 Phosphorylation PhosphoSitePlus
T1288 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
T1291 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
T1292 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
S1297 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
S1308 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
T1310 Phosphorylation PhosphoSitePlus
S1312 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1327 Phosphorylation PhosphoSitePlus
S1331 Phosphorylation PhosphoSitePlus
S1338 Phosphorylation PhosphoSitePlus
S1456 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 24275569, 20068231
T1469 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S1471 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S1522 Phosphorylation PhosphoSitePlus   UniProt 20068231
S1541 Phosphorylation PhosphoSitePlus
R1597 Methylation PhosphoSitePlus
S1616 Phosphorylation PhosphoSitePlus
S1617 Phosphorylation PhosphoSitePlus
T1662 Phosphorylation PhosphoSitePlus
S1697 Phosphorylation PhosphoSitePlus
Y1700 Phosphorylation PhosphoSitePlus
S1712 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1713 Phosphorylation PhosphoSitePlus
S1714 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T1719 Phosphorylation PhosphoSitePlus
R1775 Methylation PhosphoSitePlus
S1788 O-Glycosylation GlyGen 27114449, 30397120, 30059200, ...21740066, 29351928, 25367160, 20305658, 32119511, 28510447, 29237092
R1793 Methylation PhosphoSitePlus
R1799 Methylation PhosphoSitePlus
K1804 Methylation PhosphoSitePlus
S1823 Phosphorylation PhosphoSitePlus
R1824 Methylation PhosphoSitePlus
S1827 Phosphorylation PhosphoSitePlus
R1835 Methylation PhosphoSitePlus   UniProt 24129315
R1845 Methylation PhosphoSitePlus
K1846 Methylation PhosphoSitePlus
K1852 Acetylation PhosphoSitePlus
R1882 Methylation PhosphoSitePlus
R1893 Methylation PhosphoSitePlus   UniProt 24129315
R1894 Methylation PhosphoSitePlus   UniProt 24129315
K1901 Acetylation PhosphoSitePlus
R1904 Methylation PhosphoSitePlus
R1927 Methylation PhosphoSitePlus
R1938 Methylation PhosphoSitePlus
R1949 Methylation PhosphoSitePlus
R1960 Methylation PhosphoSitePlus
R1971 Methylation PhosphoSitePlus
S1974 Phosphorylation PhosphoSitePlus
R1977 Methylation PhosphoSitePlus   UniProt 24129315
R1982 Methylation PhosphoSitePlus   UniProt 24129315
R1993 Methylation PhosphoSitePlus   UniProt 24129315
R2008 Methylation PhosphoSitePlus   UniProt 24129315
K2020 Methylation PhosphoSitePlus
R2024 Methylation PhosphoSitePlus   UniProt 24129315
S2110 Phosphorylation PhosphoSitePlus
S2229 Phosphorylation PhosphoSitePlus
S2232 Phosphorylation PhosphoSitePlus
S2238 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S88 Phosphorylation HPRD 18452278
S111 Phosphorylation HPRD 18452278
S114 Phosphorylation HPRD 18452278
S117 Phosphorylation HPRD 18452278
T151 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S152 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S154 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S156 Phosphorylation HPRD 18669648, 17081983, 20068231
S523 Phosphorylation HPRD 20068231, 20068230
S609 Phosphorylation HPRD 18452278
S650 Phosphorylation HPRD 17924679
S677 Phosphorylation HPRD 17081983
S805 Phosphorylation HPRD 19413330, 16964243, 19664995, ...18452278, 19651622, 18669648, 20068231
S809 Phosphorylation HPRD 19413330, 16964243, 19664995, ...18452278, 19651622, 18669648, 20068231, 17081983
S811 Phosphorylation HPRD 18669648, 17081983, 18452278
S817 Phosphorylation HPRD 18669648, 17081983
S898 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S1017 Phosphorylation HPRD 18669648
S1019 Phosphorylation HPRD 18669648, 20068231
S1030 Phosphorylation HPRD 18669648, 20068231
T1035 Phosphorylation HPRD 18669648
S1040 Phosphorylation HPRD 19664995, 17081983, 19664994, ...19691289, 18452278, 19651622, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S88 Phosphorylation HPRD 18452278
S111 Phosphorylation HPRD 18452278
S114 Phosphorylation HPRD 18452278
S117 Phosphorylation HPRD 18452278
T151 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S152 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S154 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S156 Phosphorylation HPRD 18669648, 17081983, 20068231
S523 Phosphorylation HPRD 20068231, 20068230


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T33 I33 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S92 C92 Biomuta DOID:11934 / head and neck cancer [ tcga ]
T109 I109 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K383 T383 Biomuta DOID:1324 / lung cancer [ cosmic ]
S489 G489 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S501 T501 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
T502 A502 Biomuta DOID:1324 / lung cancer [ tcga ]
S504 L504 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K515 N515 Biomuta DOID:1909 / melanoma [ cosmic ]
S523 L523 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S523 A523 Biomuta DOID:1909 / melanoma [ tcga ]
T603 P603 Biomuta DOID:11054 / urinary bladder cancer [ icgc ]
K626 N626 Biomuta DOID:363 / uterine cancer [ tcga ]
K627 M627 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S660 N660 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S677 P677 Biomuta DOID:1324 / lung cancer [ tcga ]
K736 T736 Biomuta DOID:363 / uterine cancer [ tcga ]
S809 L809 Biomuta DOID:1612 / breast cancer [ tcga ]
S1005 Y1005 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S1019 F1019 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
R1039 L1039 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1242 P1242 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1254 R1254 Biomuta DOID:3571 / liver cancer [ icgc ]
S1260 L1260 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1285 T1285 Biomuta DOID:4159 / skin cancer [ icgc ]
T1310 K1310 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S1312 L1312 Biomuta DOID:1324 / lung cancer [ tcga ]
S1327 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T1469 M1469 Biomuta DOID:363 / uterine cancer [ tcga ]
S1471 F1471 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S1616 F1616 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S1617 F1617 Biomuta DOID:1909 / melanoma [ tcga ]
S1697 * Biomuta DOID:1324 / lung cancer [ tcga ]
R1775 T1775 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
R1793 * Biomuta DOID:363 / uterine cancer [ tcga ]
R1799 T1799 Biomuta DOID:1324 / lung cancer [ tcga ]
R1799 K1799 Biomuta DOID:1612 / breast cancer [ cosmic ]
R1824 K1824 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R1824 T1824 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R1845 C1845 Biomuta DOID:1324 / lung cancer [ tcga ]
K1846 N1846 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R1904 Q1904 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1904 G1904 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
R1938 W1938 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S1974 L1974 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
R1993 W1993 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S2229 L2229 Biomuta DOID:363 / uterine cancer [ tcga ]