Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BT78 / CSN4_HUMAN
Protein Name COP9 signalosome complex subunit 4
Gene Name Name: COPS4
Synonyms:CSN4;
Organism Homo sapiens (Human)

PRO ID PR:Q9BT78
DAG View
PRO Name COP9 signalosome complex subunit 4 (human)
Definition A COP9 signalosome complex subunit 4 that is encoded in the genome of human.
Short Label hCOPS4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BT78 (COPS4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 18850735
K20 Ubiquitination PhosphoSitePlus
K25 Acetylation PhosphoSitePlus   UniProt 19608861
K25 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
Y85 Phosphorylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
R271 Methylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S389 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S112 Phosphorylation HPRD 20068231
T344 Phosphorylation HPRD 20068231
S389 Phosphorylation HPRD 18491316


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y85 F85 Biomuta DOID:1324 / lung cancer [ tcga ]
Y85 C85 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R271 K271 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R271 M271 Biomuta DOID:3571 / liver cancer [ icgc ]
K337 N337 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]