Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9BSV6 / SEN34_HUMAN
Protein Name tRNA-splicing endonuclease subunit Sen34
Gene Name Name: TSEN34
Organism Homo sapiens (Human)

DAG View
PRO Name tRNA-splicing endonuclease subunit Sen34 (human)
Definition A tRNA-splicing endonuclease subunit Sen34 that is encoded in the genome of human.
Short Label hTSEN34
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9BSV6 (TSEN34) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R38 Methylation PhosphoSitePlus
S80 Phosphorylation PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Methylation PhosphoSitePlus
K87 Sumoylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K123 Ubiquitination PhosphoSitePlus
K126 Sumoylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus
S134 Phosphorylation HPRD   PhosphoSitePlus 19413330
S135 Phosphorylation HPRD   PhosphoSitePlus 19413330
S136 Phosphorylation HPRD   PhosphoSitePlus 19413330
K207 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S80 I80 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S80 N80 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K87 Q87 Biomuta DOID:1324 / lung cancer [ tcga ]
S135 A135 Biomuta DOID:363 / uterine cancer [ tcga ]
K286 N286 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]