iPTMnet Report for Q9BSQ5 (CCM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BSQ5 / CCM2_HUMAN
Protein Name Cerebral cavernous malformations 2 protein
Gene Name Name: CCM2
Synonyms:C7orf22;ORFNames:PP10187;
Organism Homo sapiens (Human)

PRO ID PR:Q9BSQ5
DAG View
PRO Name cerebral cavernous malformations 2 protein (human)
Definition A cerebral cavernous malformations 2 protein that is encoded in the genome of human.
Short Label hCCM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BSQ5 (CCM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K6 Acetylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus   UniProt 23186163
K65 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus   UniProt 24275569
S168 Phosphorylation PhosphoSitePlus
S173 O-Glycosylation GlyGen 23301498, 35132862, 29351928
S238 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
T241 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
C335 Methylation IEDB 31844290
S384 Phosphorylation O00506 (STK25) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 18669648, 18088087, 22782892
S393 O-Glycosylation GlyGen 23301498, 35132862, 29351928
S393 Phosphorylation PhosphoSitePlus
T394 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S416 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S384 Phosphorylation HPRD 18088087, 18669648, 19664994, ...18212344, 20058876
Site PTM Type PTM Enzyme Score Source PMID
S27 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S405 Phosphorylation HPRD 18088087, 18669648, 19664994, ...18212344, 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K6 M6 Biomuta DOID:1324 / lung cancer [ cosmic ]
S164 F164 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T239 A239 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S384 C384 Biomuta DOID:1324 / lung cancer [ cosmic ]
T394 I394 Biomuta DOID:4159 / skin cancer [ cosmic ]
S405 C405 Biomuta DOID:1324 / lung cancer [ cosmic ]