iPTMnet Report for Q9BSJ8 (ESYT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BSJ8 / ESYT1_HUMAN
Protein Name Extended synaptotagmin-1
Gene Name Name: ESYT1
Synonyms:FAM62A,KIAA0747,MBC2;
Organism Homo sapiens (Human)

PRO ID PR:Q9BSJ8
DAG View
PRO Name extended synaptotagmin-1 (human)
Definition An extended synaptotagmin-1 that is encoded in the genome of human.
Short Label hESYT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BSJ8 (ESYT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
S4 Phosphorylation PhosphoSitePlus
S10 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S77 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
Y121 Phosphorylation PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
R170 Methylation PhosphoSitePlus
K189 Acetylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
S324 Phosphorylation neXtProt   PhosphoSitePlus 19255425
K344 Ubiquitination PhosphoSitePlus
Y347 Phosphorylation IEDB   PhosphoSitePlus 35494241
K349 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus
Y359 Phosphorylation PhosphoSitePlus
T366 Phosphorylation PhosphoSitePlus
C370 S-Nitrosylation dbSNO 26338901
K409 Ubiquitination PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
S506 Phosphorylation PhosphoSitePlus
T511 Phosphorylation PhosphoSitePlus
S514 Phosphorylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
Y588 Phosphorylation PhosphoSitePlus
S627 Phosphorylation PhosphoSitePlus
S641 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...34725712, 34019948, 29351928, 35132862, 35083852
K662 Ubiquitination PhosphoSitePlus
K671 Ubiquitination PhosphoSitePlus
Y677 Phosphorylation PhosphoSitePlus
K679 Acetylation PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K817 Acetylation PhosphoSitePlus   UniProt 19608861
K817 Ubiquitination PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
Y822 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 18083107
T824 Phosphorylation PhosphoSitePlus
T826 Phosphorylation PhosphoSitePlus
S830 Phosphorylation PhosphoSitePlus
S831 Phosphorylation PhosphoSitePlus
K833 Ubiquitination PhosphoSitePlus
K835 Ubiquitination PhosphoSitePlus
K855 Ubiquitination PhosphoSitePlus
S860 Phosphorylation PhosphoSitePlus
T896 Phosphorylation PhosphoSitePlus
S928 Phosphorylation PhosphoSitePlus
S933 Phosphorylation PhosphoSitePlus
S941 Phosphorylation PhosphoSitePlus   UniProt 24275569
T948 Phosphorylation PhosphoSitePlus   UniProt 24275569
S949 Phosphorylation PhosphoSitePlus   UniProt 24275569
S950 Phosphorylation PhosphoSitePlus
T959 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S963 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
Y981 Phosphorylation PhosphoSitePlus
Y982 Phosphorylation PhosphoSitePlus
K987 Ubiquitination PhosphoSitePlus
Y1009 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 18083107
S1011 O-Glycosylation GlyGen 23301498, 27655845, 33214551, ...34725712, 34019948, 29351928, 35132862, 35083852
S1011 Phosphorylation PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
T1022 Phosphorylation PhosphoSitePlus
S1034 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
K1054 Ubiquitination PhosphoSitePlus
S1058 Phosphorylation PhosphoSitePlus
K1060 Ubiquitination PhosphoSitePlus
S1063 Phosphorylation PhosphoSitePlus
S1064 Phosphorylation PhosphoSitePlus
S1067 Phosphorylation PhosphoSitePlus
K1075 Ubiquitination PhosphoSitePlus
K1099 Ubiquitination PhosphoSitePlus
S1104 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S820 Phosphorylation HPRD 18578522, 20068231
Y822 Phosphorylation HPRD 15592455, 18578522, 20068231
S841 Phosphorylation HPRD 20068231
T959 Phosphorylation HPRD 18669648, 20068231
S963 Phosphorylation HPRD 18578522, 18669648, 20068231, ...17924679
Y1009 Phosphorylation HPRD 15592455, 18083107
S1034 Phosphorylation HPRD 18578522, 19664994, 20058876, ...19651622, 18669648, 18707149
Site PTM Type PTM Enzyme Score Source PMID
T494 Phosphorylation PhosphoSitePlus
S495 Phosphorylation PhosphoSitePlus
Y498 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K118 N118 Biomuta DOID:9256 / colorectal cancer [ icgc ]
Y121 C121 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S324 F324 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S356 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T366 I366 Biomuta DOID:4159 / skin cancer [ cosmic ]
K497 E497 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S514 N514 Biomuta DOID:4159 / skin cancer [ cosmic ]
K727 E727 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S831 F831 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S841 L841 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S928 N928 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S963 C963 Biomuta DOID:3571 / liver cancer [ cosmic ]
K987 R987 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1009 C1009 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1011 L1011 Biomuta DOID:1324 / lung cancer [ cosmic ]
K1018 R1018 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K1054 Q1054 Biomuta DOID:3571 / liver cancer [ cosmic ]
S1104 F1104 Biomuta DOID:4159 / skin cancer [ cosmic ]