iPTMnet Report for Q9BRZ2 (TRIM56)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BRZ2 / TRI56_HUMAN
Protein Name E3 ubiquitin-protein ligase TRIM56
Gene Name Name: TRIM56
Synonyms:RNF109;
Organism Homo sapiens (Human)

PRO ID PR:Q9BRZ2
DAG View
PRO Name E3 ubiquitin-protein ligase TRIM56 (human)
Definition An E3 ubiquitin-protein ligase TRIM56 that is encoded in the genome of human.
Short Label hTRIM56
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BRZ2 (TRIM56) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation PhosphoSitePlus
S6 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
T253 Phosphorylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
S369 Phosphorylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K381 Ubiquitination PhosphoSitePlus
S392 O-Glycosylation GlyGen 30379171
S392 Phosphorylation PhosphoSitePlus
S394 O-Glycosylation GlyGen 30379171
T418 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163, 24275569
T442 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
S469 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S471 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S475 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983
K688 Ubiquitination PhosphoSitePlus
S710 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 18691976
T418 Phosphorylation HPRD 18691976
T442 Phosphorylation HPRD 18691976
S469 Phosphorylation HPRD 19651622, 18691976, 17081983
S471 Phosphorylation HPRD 18691976, 17081983
S475 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 F3 Biomuta DOID:4159 / skin cancer [ cosmic ]
S475 R475 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]