iPTMnet Report for Q9BRV8 (SIKE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BRV8 / SIKE1_HUMAN
Protein Name Suppressor of IKBKE 1
Gene Name Name: SIKE1
Synonyms:SIKE;
Organism Homo sapiens (Human)

PRO ID PR:Q9BRV8
DAG View
PRO Name suppressor of IKBKE 1 (human)
Definition A suppressor of IKK-epsilon that is encoded in the genome of human.
Short Label hSIKE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BRV8 (SIKE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K13 Ubiquitination PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S74 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K120 Ubiquitination PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
S133 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus   RLIMS-P 23649622
C146 Methylation IEDB 31844290
K154 Ubiquitination PhosphoSitePlus
C164 Methylation IEDB 31844290
K165 Ubiquitination PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
S185 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus 23649622
S187 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus 23649622
S188 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus 23649622
S190 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus 23649622
K195 Ubiquitination PhosphoSitePlus
S198 Phosphorylation Q9UHD2 (TBK1) PhosphoSitePlus 23649622
Site PTM Type PTM Enzyme Score Source PMID
S74 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K13 N13 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K62 Q62 Biomuta DOID:263 / kidney cancer [ cosmic ]
K120 T120 Biomuta DOID:1319 / brain cancer [ icgc ]