iPTMnet Report for Q9BRT9 (GINS4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BRT9 / SLD5_HUMAN
Protein Name DNA replication complex GINS protein SLD5
Gene Name Name: GINS4
Synonyms:SLD5;
Organism Homo sapiens (Human)

PRO ID PR:Q9BRT9
DAG View
PRO Name DNA replication complex GINS protein SLD5 (human)
Definition A DNA replication complex GINS protein SLD5 that is encoded in the genome of human.
Short Label hGINS4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BRT9 (GINS4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 20068231
T2 Acetylation UniProt 21406692
T2 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
S16 Phosphorylation PhosphoSitePlus   UniProt 21406692, 20068231
T22 Phosphorylation PhosphoSitePlus
K47 Sumoylation PhosphoSitePlus
Y87 Phosphorylation PhosphoSitePlus
Y92 Phosphorylation PhosphoSitePlus
R94 Methylation PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
T210 Phosphorylation PhosphoSitePlus
S217 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation HPRD 17081983
S12 Phosphorylation HPRD 17081983, 20068231
S16 Phosphorylation HPRD 17081983, 20068231
T22 Phosphorylation HPRD 17081983, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T2 I2 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S12 F12 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
K102 N102 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S123 W123 Biomuta DOID:1324 / lung cancer [ cosmic ]
K164 R164 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]