iPTMnet Report for Q9BRQ8 (AIFM2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BRQ8 / FSP1_HUMAN
Protein Name Ferroptosis suppressor protein 1
Gene Name Name: AIFM2
Synonyms:AMID;
Organism Homo sapiens (Human)

PRO ID PR:Q9BRQ8
DAG View
PRO Name ferroptosis suppressor protein 1 (human)
Definition A ferroptosis suppressor protein 1 that is encoded in the genome of human.
Short Label hAIFM2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BRQ8 (AIFM2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 31634899, 31634900, 25255805, ...20213681
K63 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
S356 O-Glycosylation GlyGen 30379171
S362 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y220 F220 Biomuta DOID:1324 / lung cancer [ cosmic ]
S331 Y331 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y345 C345 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y345 S345 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S362 C362 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]