iPTMnet Report for Q9BRQ0 (PYGO2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BRQ0 / PYGO2_HUMAN
Protein Name Pygopus homolog 2
Gene Name Name: PYGO2
ORFNames:PP7910;
Organism Homo sapiens (Human)

PRO ID PR:Q9BRQ0
DAG View
PRO Name pygopus homolog 2 (human)
Definition A pygopus homolog 2 that is encoded in the genome of human.
Short Label hPYGO2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BRQ0 (PYGO2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330
S26 Phosphorylation PhosphoSitePlus
T27 Phosphorylation PhosphoSitePlus
S40 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S48 Phosphorylation P31749 (AKT1) HPRD   PhosphoSitePlus 20068231, 26170450
T50 Phosphorylation PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
T66 Phosphorylation PhosphoSitePlus
S97 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 17924679
R105 Methylation PhosphoSitePlus
T120 Phosphorylation PhosphoSitePlus
R130 Methylation PhosphoSitePlus
R131 Methylation PhosphoSitePlus
T302 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 23186163, 16964243, ...18767875, 19664994, 19664995, 19651622, 17322306, 18669648, 24275569, 19415658, 20068231, 18212344
S307 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R105 H105 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R130 H130 Biomuta DOID:3571 / liver cancer [ cosmic ]
R130 C130 Biomuta DOID:4159 / skin cancer [ cosmic ]