iPTMnet Report for Q9BRL6 (SRSF8)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BRL6 / SRSF8_HUMAN
Protein Name Serine/arginine-rich splicing factor 8
Gene Name Name: SRSF8
Synonyms:SFRS2B,SRP46;
Organism Homo sapiens (Human)

PRO ID PR:Q9BRL6
DAG View
PRO Name serine/arginine-rich splicing factor 8 (human)
Definition A serine/arginine-rich splicing factor 8 that is encoded in the genome of human.
Short Label hSRSF8
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BRL6 (SRSF8) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
T25 Phosphorylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus   UniProt 23186163
S29 Phosphorylation PhosphoSitePlus
R31 Methylation PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
R39 Methylation PhosphoSitePlus
Y44 Phosphorylation PhosphoSitePlus
R55 Methylation PhosphoSitePlus
S100 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
R106 Methylation PhosphoSitePlus
R110 Methylation PhosphoSitePlus
S134 Phosphorylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus   UniProt 23186163
S158 Phosphorylation IEDB   PhosphoSitePlus   UniProt 27920218, 23186163
Y160 Phosphorylation PhosphoSitePlus
S161 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
S168 Phosphorylation PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus   UniProt 23186163
S173 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y175 Phosphorylation PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus
Y190 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S198 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
K233 Methylation PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S240 Phosphorylation PhosphoSitePlus
R241 Methylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S267 Phosphorylation PhosphoSitePlus
S273 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S281 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S282 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
Y23 Phosphorylation HPRD 20068231
T25 Phosphorylation HPRD 18767875, 20068231
S26 Phosphorylation HPRD 20068231
S29 Phosphorylation HPRD 20068231
S100 Phosphorylation HPRD 17081983, 20068231
S196 Phosphorylation HPRD 20068231
S236 Phosphorylation HPRD 19651622
S238 Phosphorylation HPRD 19651622
S240 Phosphorylation HPRD 19651622
S273 Phosphorylation HPRD 18669648
S281 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 I2 Biomuta DOID:1612 / breast cancer [ cosmic ]
R55 L55 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S153 Y153 Biomuta DOID:363 / uterine cancer [ cosmic ]
S178 F178 Biomuta DOID:363 / uterine cancer [ cosmic ]
S191 N191 Biomuta DOID:363 / uterine cancer [ cosmic ]
S236 L236 Biomuta DOID:1324 / lung cancer [ cosmic ]
S236 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
R241 G241 Biomuta DOID:1612 / breast cancer [ cosmic, tcga ]
S281 C281 Biomuta DOID:3571 / liver cancer [ cosmic ]