iPTMnet Report for Q9BRK4 (LZTS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BRK4 / LZTS2_HUMAN
Protein Name Leucine zipper putative tumor suppressor 2
Gene Name Name: LZTS2
Synonyms:KIAA1813,LAPSER1;
Organism Homo sapiens (Human)

PRO ID PR:Q9BRK4
DAG View
PRO Name leucine zipper putative tumor suppressor 2 (human)
Definition A leucine zipper putative tumor suppressor 2 that is encoded in the genome of human.
Short Label hLZTS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BRK4 (LZTS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T97 Phosphorylation PhosphoSitePlus
S99 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
S105 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
R168 Methylation PhosphoSitePlus
S173 O-Glycosylation GlyGen 25813380
S175 Phosphorylation PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S193 Phosphorylation PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S224 Phosphorylation PhosphoSitePlus
R254 Methylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
S273 Phosphorylation PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
S296 Phosphorylation HPRD   PhosphoSitePlus 19664994
T298 Phosphorylation PhosphoSitePlus
S301 Phosphorylation PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
T424 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
T546 Phosphorylation PhosphoSitePlus
S555 Phosphorylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
S570 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 21406692, 23186163, ...19664995
K607 Methylation PhosphoSitePlus
K615 Acetylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S104 I104 Biomuta DOID:363 / uterine cancer [ icgc ]
S105 G105 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S160 F160 Biomuta DOID:4159 / skin cancer [ cosmic ]
R168 W168 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S191 C191 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc, tcga ]
S193 F193 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S220 Y220 Biomuta DOID:1319 / brain cancer [ icgc ]
R254 Q254 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R254 * Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S269 P269 Biomuta DOID:1612 / breast cancer [ cosmic ]
S277 F277 Biomuta DOID:4159 / skin cancer [ cosmic ]
S301 A301 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S301 C301 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S301 F301 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]