Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9BRG2 / SH23A_HUMAN
Protein Name SH2 domain-containing protein 3A
Gene Name Name: SH2D3A
Organism Homo sapiens (Human)

DAG View
PRO Name SH2 domain-containing protein 3A (human)
Definition An SH2 domain-containing protein 3A that is encoded in the genome of human.
Short Label hSH2D3A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9BRG2 (SH2D3A) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y16 Phosphorylation phospho.ELM 10187783
K24 Ubiquitination PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation phospho.ELM   PhosphoSitePlus 10187783
S123 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
S125 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
T128 Phosphorylation PhosphoSitePlus
S145 Phosphorylation PhosphoSitePlus
S147 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S158 Phosphorylation PhosphoSitePlus
T178 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S180 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
T193 Phosphorylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T216 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
T230 Phosphorylation PhosphoSitePlus
Y231 Phosphorylation phospho.ELM   PhosphoSitePlus 10187783
S245 Phosphorylation PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
R548 Methylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y16 Phosphorylation HPRD 10187783
Y95 Phosphorylation HPRD 10187783
S123 Phosphorylation HPRD 18669648, 20068231
S125 Phosphorylation HPRD 19651622, 18767875, 18669648, ...19664994, 19415658
S145 Phosphorylation HPRD 19651622, 20068231
S180 Phosphorylation HPRD 19413330, 18669648, 19664994
S201 Phosphorylation HPRD 18669648
Y231 Phosphorylation HPRD 10187783

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04626 (ERBB2) Y1222 Q9BRG2 (SH2D3A) unknown eFIP 16273093

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S197 N197 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S201 P201 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
R548 Q548 Biomuta DOID:363 / uterine cancer [ tcga ]