iPTMnet Report for Q9BRG2 (SH2D3A)
Protein Information
UniProt AC / UniProt ID | Q9BRG2 / SH23A_HUMAN |
Protein Name | SH2 domain-containing protein 3A |
Gene Name | Name: SH2D3A Synonyms:NSP1;ORFNames:UNQ175/PRO201; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9BRG2 |
PRO Name | SH2 domain-containing protein 3A (human) |
Definition | An SH2 domain-containing protein 3A that is encoded in the genome of human. |
Short Label | hSH2D3A |
Category | organism-gene |
Q9BRG2 (SH2D3A) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y16 | Phosphorylation | score2 | phospho.ELM | 10187783 | ||
K24 | Ubiquitination | score1 | PhosphoSitePlus | |||
S56 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y95 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 10187783 | ||
S123 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 20068231 | ||
S125 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 21406692 | ||
T128 | Phosphorylation | score1 | PhosphoSitePlus | |||
S145 | Phosphorylation | score1 | PhosphoSitePlus | |||
S147 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163 | ||
S158 | Phosphorylation | score1 | PhosphoSitePlus | |||
T178 | Phosphorylation | score1 | PhosphoSitePlus | |||
S179 | Phosphorylation | score1 | PhosphoSitePlus | |||
S180 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 21406692 | ||
T193 | Phosphorylation | score1 | PhosphoSitePlus | |||
S197 | Phosphorylation | score1 | PhosphoSitePlus | |||
S201 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163 | ||
T216 | Phosphorylation | score1 | PhosphoSitePlus | |||
S218 | Phosphorylation | score1 | PhosphoSitePlus | |||
T230 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y231 | Phosphorylation | score3 | phospho.ELM PhosphoSitePlus | 10187783 | ||
S245 | Phosphorylation | score1 | PhosphoSitePlus | |||
K451 | Ubiquitination | score1 | PhosphoSitePlus | |||
R548 | Methylation | score1 | PhosphoSitePlus | |||
K560 | Ubiquitination | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y16 | Phosphorylation | score1 | HPRD | 10187783 | ||
Y95 | Phosphorylation | score1 | HPRD | 10187783 | ||
S123 | Phosphorylation | score0 | HPRD | 18669648, 20068231 | ||
S125 | Phosphorylation | score0 | HPRD | 19651622, 18767875, 18669648, ... | ||
S145 | Phosphorylation | score0 | HPRD | 19651622, 20068231 | ||
S180 | Phosphorylation | score0 | HPRD | 19413330, 18669648, 19664994 | ||
S201 | Phosphorylation | score0 | HPRD | 18669648 | ||
Y231 | Phosphorylation | score1 | HPRD | 10187783 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S145 | G145 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S197 | N197 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
S201 | P201 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
S218 | F218 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T230 | M230 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
R548 | Q548 | Biomuta | DOID:363 / uterine cancer [ icgc ] |