iPTMnet Report for Q9BR39 (JPH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BR39 / JPH2_HUMAN
Protein Name Junctophilin-2
Gene Name Name: JPH2
Synonyms:JP2;
Organism Homo sapiens (Human)

PRO ID PR:Q9BR39
DAG View
PRO Name junctophilin-2 (human)
Definition A junctophilin-2 that is encoded in the genome of human.
Short Label hJPH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BR39 (JPH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y141 Phosphorylation PhosphoSitePlus
S157 Phosphorylation phospho.ELM   PhosphoSitePlus 18220336
S162 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S165 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   RLIMS-P   UniProt 20095964, 22389502
S168 Phosphorylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
S247 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
S309 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S359 Phosphorylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S469 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
T477 Phosphorylation PhosphoSitePlus
S484 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S486 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983
T490 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17081983, 24275569
S502 Phosphorylation PhosphoSitePlus
S508 Phosphorylation PhosphoSitePlus
S534 Phosphorylation PhosphoSitePlus
K647 Acetylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K651 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T161 Phosphorylation HPRD 17081983
S162 Phosphorylation HPRD 17081983
S359 Phosphorylation HPRD 19664994
S469 Phosphorylation HPRD 19651622, 18767875, 17081983
T477 Phosphorylation HPRD 19651622
S484 Phosphorylation HPRD 18669648
S486 Phosphorylation HPRD 19651622, 18669648, 17081983
T490 Phosphorylation HPRD 19651622, 18669648, 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S157 L157 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T161 M161 Biomuta DOID:363 / uterine cancer [ icgc ]
S164 L164 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S179 F179 Biomuta DOID:4159 / skin cancer [ cosmic ]
S309 F309 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S310 G310 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S359 N359 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]