iPTMnet Report for Q9BQP7 (MGME1)
Protein Information
UniProt AC / UniProt ID | Q9BQP7 / MGME1_HUMAN |
Protein Name | Mitochondrial genome maintenance exonuclease 1 |
Gene Name | Name: MGME1 Synonyms:C20orf72,DDK1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:Q9BQP7 |
PRO Name | mitochondrial genome maintenance exonuclease 1 (human) |
Definition | A mitochondrial genome maintenance exonuclease 1 that is encoded in the genome of human. |
Short Label | hMGME1 |
Category | organism-gene |
Q9BQP7 (MGME1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S15 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
S16 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
S29 | Phosphorylation | score1 | PhosphoSitePlus | |||
T30 | Phosphorylation | score1 | PhosphoSitePlus | |||
K51 | Ubiquitination | score1 | PhosphoSitePlus | |||
K84 | Ubiquitination | score1 | PhosphoSitePlus | |||
K86 | Ubiquitination | score1 | PhosphoSitePlus | |||
K111 | Ubiquitination | score1 | PhosphoSitePlus | |||
K122 | Ubiquitination | score1 | PhosphoSitePlus | |||
K194 | Ubiquitination | score1 | PhosphoSitePlus | |||
K202 | Ubiquitination | score1 | PhosphoSitePlus | |||
S315 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y317 | Phosphorylation | score1 | PhosphoSitePlus | |||
T319 | Phosphorylation | score1 | PhosphoSitePlus | |||
K333 | Methylation | score1 | PhosphoSitePlus | |||
Y342 | Phosphorylation | score1 | PhosphoSitePlus | |||
S343 | Phosphorylation | score2 | HPRD phospho.ELM PhosphoSitePlus UniProt | 19413330, 18669648, 19664994 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
S15 | C15 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] | |
S29 | C29 | Biomuta | DOID:2531 / hematologic cancer [ icgc ] | |
K111 | T111 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
S315 | C315 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
S315 | T315 | Biomuta | DOID:1612 / breast cancer [ cosmic, icgc ] | |
K333 | N333 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] |