Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9BQP7 / MGME1_HUMAN
Protein Name Mitochondrial genome maintenance exonuclease 1
Gene Name Name: MGME1
Organism Homo sapiens (Human)

DAG View
PRO Name mitochondrial genome maintenance exonuclease 1 (human)
Definition A mitochondrial genome maintenance exonuclease 1 that is encoded in the genome of human.
Short Label hMGME1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9BQP7 (MGME1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S15 Phosphorylation HPRD   PhosphoSitePlus 20068231
S16 Phosphorylation HPRD   PhosphoSitePlus 20068231
S29 Phosphorylation PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus
K333 Methylation PhosphoSitePlus
Y342 Phosphorylation PhosphoSitePlus
S343 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18669648, 19664994

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S15 C15 Biomuta DOID:5041 / esophageal cancer [ icgc ]
K111 T111 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S315 C315 Biomuta DOID:1612 / breast cancer [ tcga ]
S315 T315 Biomuta DOID:1612 / breast cancer [ tcga ]
K333 N333 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]