iPTMnet Report for Q9BQI3 (EIF2AK1)
Protein Information
| UniProt AC / UniProt ID | Q9BQI3 / E2AK1_HUMAN |
| Protein Name | Eukaryotic translation initiation factor 2-alpha kinase 1 |
| Gene Name | Name: EIF2AK1 Synonyms:HRI;ORFNames:PRO1362; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q9BQI3 |
| PRO Name | eukaryotic translation initiation factor 2-alpha kinase 1 (human) |
| Definition | A eukaryotic translation initiation factor 2-alpha kinase 1 that is encoded in the genome of human. |
| Short Label | hEIF2AK1 |
| Category | organism-gene |
DAG ViewQ9BQI3 (EIF2AK1) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S144 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K175 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K187 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y193 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K196 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K201 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K210 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S253 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S258 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S274 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S275 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S276 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T285 | Phosphorylation | score2 | IEDB PhosphoSitePlus | 32897882 | ||
| K288 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S295 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T297 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K303 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K472 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S498 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K558 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K602 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K609 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K618 | Ubiquitination | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S6 | Phosphorylation | score0 | HPRD | 18691976 | ||
| Y38 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S258 | Phosphorylation | score0 | HPRD | 18691976, 19664994, 18452278 | ||
| S274 | Phosphorylation | score0 | HPRD | 18691976 | ||
| S275 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S276 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S277 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S278 | Phosphorylation | score0 | HPRD | 18691976, 17081983 | ||
| S295 | Phosphorylation | score0 | HPRD | 18691976 |
Q9BQI3 (EIF2AK1) as PTM Enzyme
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K210 | M210 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S276 | I276 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| S276 | C276 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S277 | A277 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| S278 | F278 | Biomuta | [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ] | |
| T297 | I297 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| T297 | A297 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K472 | R472 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| K558 | R558 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic, icgc ] |
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