Protein Information

Cytoscape View

UniProt AC / UniProt ID Q9BQ61 / TRIR_HUMAN
Protein Name Telomerase RNA component interacting RNase
Gene Name Name: TRIR
Organism Homo sapiens (Human)

DAG View
PRO Name telomerase RNA component interacting RNase (human)
Definition A telomerase RNA component interacting RNase that is encoded in the genome of human.
Short Label hTRIR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

Q9BQ61 (TRIR) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
R4 Methylation PhosphoSitePlus
R6 Methylation PhosphoSitePlus
R7 Methylation PhosphoSitePlus
R13 Methylation PhosphoSitePlus
S26 Phosphorylation PhosphoSitePlus
S36 Phosphorylation HPRD   PhosphoSitePlus 18452278
S39 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S45 Phosphorylation HPRD   PhosphoSitePlus 18452278
S49 Phosphorylation HPRD   PhosphoSitePlus 18452278
S50 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
S53 Phosphorylation HPRD   PhosphoSitePlus 18452278
K72 Acetylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
T112 Phosphorylation HPRD   PhosphoSitePlus 18212344
S114 Phosphorylation PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K118 Methylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K124 Acetylation PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Methylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
T138 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340
T144 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus   UniProt 19608861
K146 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
K170 Acetylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K176 Acetylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036366 (hTRIR/Ac:1) acM1 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 L53 Biomuta DOID:1909 / melanoma [ cosmic ]
T138 M138 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
T138 K138 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K146 E146 Biomuta DOID:363 / uterine cancer [ tcga ]