iPTMnet Report for Q9BQ39 (DDX50)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BQ39 / DDX50_HUMAN
Protein Name ATP-dependent RNA helicase DDX50
Gene Name Name: DDX50
Organism Homo sapiens (Human)

PRO ID PR:Q9BQ39
DAG View
PRO Name ATP-dependent RNA helicase DDX50 (human)
Definition An ATP-dependent RNA helicase DDX50 that is encoded in the genome of human.
Short Label hDDX50
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BQ39 (DDX50) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S35 Phosphorylation PhosphoSitePlus
Y39 Phosphorylation PhosphoSitePlus
S41 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
S45 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 20068231
T47 Phosphorylation HPRD   PhosphoSitePlus 20068231
T53 Phosphorylation HPRD   PhosphoSitePlus 19651622
T74 Phosphorylation HPRD   PhosphoSitePlus 20068231
S82 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S86 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K87 Ubiquitination PhosphoSitePlus
K94 Acetylation PhosphoSitePlus
Y104 Phosphorylation PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T116 Phosphorylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K135 Sumoylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K150 Sumoylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
T188 Phosphorylation HPRD 20068231
S211 Phosphorylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
T266 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
Y345 Phosphorylation PhosphoSitePlus
K353 Ubiquitination PhosphoSitePlus
K412 Ubiquitination PhosphoSitePlus
K432 Methylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus
Y472 Phosphorylation PhosphoSitePlus
K506 Ubiquitination PhosphoSitePlus
K512 Methylation PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
S518 Phosphorylation HPRD 20068231
T519 Phosphorylation HPRD 20068231
K524 Ubiquitination PhosphoSitePlus
K606 Acetylation PhosphoSitePlus
K611 Ubiquitination PhosphoSitePlus
S673 Phosphorylation PhosphoSitePlus
S676 Phosphorylation PhosphoSitePlus
S683 Phosphorylation PhosphoSitePlus
S713 Phosphorylation PhosphoSitePlus
S735 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S41 L41 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
T53 R53 Biomuta DOID:1319 / brain cancer [ cosmic ]
T74 A74 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S112 L112 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K150 T150 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T188 A188 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T322 S322 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
T322 I322 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K412 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T519 A519 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S683 A683 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S713 I713 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]