Protein Information

Cytoscape View


UniProt AC / UniProt ID Q9BPZ7 / SIN1_HUMAN
Protein Name Target of rapamycin complex 2 subunit MAPKAP1
Gene Name Name: MAPKAP1
Synonyms:MIP1,SIN1;
Organism Homo sapiens (Human)

PRO ID PR:Q9BPZ7
DAG View
PRO Name target of rapamycin complex 2 subunit MAPKAP1 (human)
Definition A target of rapamycin complex 2 subunit MAPKAP1 that is encoded in the genome of human.
Short Label hMAPKAP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q9BPZ7 (MAPKAP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S84 Phosphorylation PhosphoSitePlus
T86 Phosphorylation P31749 (AKT1) PhosphoSitePlus   RLIMS-P 33158864, 24161930, 24481632, ...26235620, 23684622
K121 Ubiquitination PhosphoSitePlus
S128 Phosphorylation PhosphoSitePlus   RLIMS-P 30837283
K162 Ubiquitination PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S185 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus   UniProt 23186163
S260 Phosphorylation P42345 (MTOR) PhosphoSitePlus 23928304
S270 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K302 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus   RLIMS-P 30837283
S356 Phosphorylation RLIMS-P 30837283
S367 Phosphorylation PhosphoSitePlus
T398 Phosphorylation RLIMS-P 24161930, 24481632, 33158864
K428 Ubiquitination PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
T509 Phosphorylation PhosphoSitePlus
S510 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S512 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S270 Phosphorylation HPRD 18691976
S510 Phosphorylation HPRD 18691976, 18669648, 17081983, ...18767875
S512 Phosphorylation HPRD 18767875
Site PTM Type PTM Enzyme Score Source PMID
S270 Phosphorylation HPRD 18691976
K317 Ubiquitination PhosphoSitePlus
S474 Phosphorylation HPRD 18691976, 18669648, 17081983, ...18767875
S476 Phosphorylation HPRD 18767875
Site PTM Type PTM Enzyme Score Source PMID
S270 Phosphorylation HPRD 18691976
S463 Phosphorylation HPRD 18691976, 18669648, 17081983, ...18767875
S465 Phosphorylation HPRD 18767875
Site PTM Type PTM Enzyme Score Source PMID
S78 Phosphorylation HPRD 18691976
S318 Phosphorylation HPRD 18691976, 18669648, 17081983, ...18767875
S320 Phosphorylation HPRD 18767875
Site PTM Type PTM Enzyme Score Source PMID
S270 Phosphorylation HPRD 18691976


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P42345 (MTOR) S2481 Q9BPZ7 (MAPKAP1) unknown eFIP 21045808
Phosphorylation Q9BPZ7 (MAPKAP1) T398 Q3U182 (Crtc2) unknown eFIP 31798957
Phosphorylation Q9BPZ7 (MAPKAP1) T398 Q3U182 (Crtc2) unknown eFIP 24481632


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S84 L84 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T86 K86 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S185 L185 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S367 L367 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S449 I449 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S459 N459 Biomuta DOID:4362 / cervical cancer [ cosmic ]
K501 E501 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T509 M509 Biomuta DOID:4362 / cervical cancer [ tcga ]