iPTMnet Report for Q99N57 (Raf1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99N57 / RAF1_MOUSE
Protein Name RAF proto-oncogene serine/threonine-protein kinase
Gene Name Name: Raf1
Synonyms:Craf;
Organism Mus musculus (Mouse)

PRO ID PR:Q99N57
DAG View
PRO Name RAF proto-oncogene serine/threonine-protein kinase (mouse)
Definition A RAF proto-oncogene serine/threonine-protein kinase that is encoded in the genome of mouse.
Short Label mRAF1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99N57 (Raf1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation PhosphoSitePlus
S29 Phosphorylation P63085 (Mapk1) PhosphoSitePlus   Signor   UniProt 15664191
T31 Phosphorylation PhosphoSitePlus
S43 Phosphorylation P63085 (Mapk1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11997508, 10862777, 8349614, ...15664191
T57 Phosphorylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
S220 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S233 Phosphorylation P05132 (Prkaca) phospho.ELM   PhosphoSitePlus   RLIMS-P 11997508
T234 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
S244 Phosphorylation PhosphoSitePlus
T258 Phosphorylation PhosphoSitePlus
S259 Phosphorylation P31750 (Akt1) phospho.ELM   PhosphoSitePlus   RLIMS-P 11782426, 21926268, 12087097, ...23509299, 22826029, 12675918, 8349614, 28210689, 11997508, 1741164, 8321321
S289 Phosphorylation P63085 (Mapk1) , Q63844 (Mapk3) PhosphoSitePlus   Signor   UniProt 15664191
S291 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
S296 Phosphorylation Q63844 (Mapk3) , P63085 (Mapk1) PhosphoSitePlus   Signor   UniProt 21183079, 15664191
S301 Phosphorylation P63085 (Mapk1) PhosphoSitePlus   Signor   UniProt 21183079, 15664191
T303 Phosphorylation PhosphoSitePlus
S306 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
S338 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 11782426, 11997508, 15238444, ...22081024, 21926268, 30127380, 22826029, 12604616, 15379891, 15026317, 11259591, 20926779, 18706973, 10205168
S339 Phosphorylation PhosphoSitePlus
Y340 Phosphorylation Q62120 (Jak2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 30127380, 11296227, 8876196, ...7692235
Y341 Phosphorylation Q62120 (Jak2) , P05480 (Src) , P25911 (Lyn) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 8876196, 11716471, 30127380, ...7692235, 10205168
T491 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus   RLIMS-P 8288587
S499 Phosphorylation phospho.ELM   RLIMS-P 8321321
S612 Phosphorylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus   RLIMS-P 8288587
S621 Phosphorylation Q99N57 (Raf1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11782426, 18922468, 8349614, ...15664191, 11262401
S624 Phosphorylation PhosphoSitePlus
T641 Phosphorylation PhosphoSitePlus
S642 Phosphorylation P63085 (Mapk1) PhosphoSitePlus   Signor   UniProt 21183079, 15664191


Q99N57 (Raf1) as PTM Enzyme



Substrate Site Score Source PMID
Q99N57 (Raf1) S621 PhosphoSitePlus 18922468


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q99N57 (Raf1) S338 Q07832 (Plk1) unknown eFIP 22081024
Phosphorylation Q9QUR7 (Pin1) S16 Q99N57 (Raf1) inhibited_association eFIP 21400615