Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99986 / VRK1_HUMAN
Protein Name Serine/threonine-protein kinase VRK1
Gene Name Name: VRK1
Organism Homo sapiens (Human)

PRO ID PR:Q99986
DAG View
PRO Name serine/threonine-protein kinase VRK1 (human)
Definition A serine/threonine-protein kinase VRK1 that is encoded in the genome of human.
Short Label hVRK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99986 (VRK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K5 Methylation PhosphoSitePlus
K5 Sumoylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K92 Sumoylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K98 Acetylation PhosphoSitePlus
K98 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K112 Sumoylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K121 Ubiquitination PhosphoSitePlus
K140 Acetylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K147 Acetylation PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K152 Sumoylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
T153 Phosphorylation HPRD   PhosphoSitePlus 19664994
S158 Phosphorylation HPRD   PhosphoSitePlus 19664994
K188 Ubiquitination PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K269 Sumoylation PhosphoSitePlus
K269 Ubiquitination PhosphoSitePlus
K275 Sumoylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K293 Acetylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
T305 Phosphorylation HPRD   phospho.ELM 11883897
K307 Sumoylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
K334 Acetylation PhosphoSitePlus
K338 Sumoylation PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
S342 Phosphorylation Q9H4B4 (PLK3) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19103756, 23186163, 20068231
K350 Sumoylation PhosphoSitePlus
T355 Phosphorylation Q05655 (PRKCD) , Q99986 (VRK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11883897, 21346188
S376 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18452278
T378 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18077418, 23186163
T380 Phosphorylation PhosphoSitePlus
T390 Phosphorylation HPRD   phospho.ELM 11883897


Q99986 (VRK1) as PTM Enzyme



Substrate Site Score Source PMID
O60934 (NBN) S343 RLIMS-P+ 26869104
O75531 (BANF1) T2 PhosphoSitePlus   Signor 16495336
O75531 (BANF1) T3 PhosphoSitePlus   Signor 16495336
O75531 (BANF1) S4 PhosphoSitePlus   Signor 16371512, 16495336
P04637-1 (TP53) T18 HPRD   phospho.ELM   PhosphoSitePlus   Signor 15542844, 10747897, 10951572, ...11883897, 11709713
P05412 (JUN) S63 phospho.ELM   PhosphoSitePlus   Signor 15378002
P05412 (JUN) S73 phospho.ELM   PhosphoSitePlus   Signor 15378002
P15336 (ATF2) S62 PhosphoSitePlus   Signor 15105425
P15336 (ATF2) T73 PhosphoSitePlus   Signor 15105425
P16220 (CREB1) S133 RLIMS-P+ 18713830
P38432 (COIL) S184 PhosphoSitePlus 21920476
P68431 (H3C12) T4 phospho.ELM 17938195
P68431 (H3C12) S11 phospho.ELM   Signor 17938195
Q99986 (VRK1) T355 PhosphoSitePlus   UniProt 11883897


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K34 Q34 Biomuta DOID:363 / uterine cancer [ tcga ]
S75 I75 Biomuta DOID:3571 / liver cancer [ icgc ]
K85 Q85 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K112 N112 Biomuta DOID:3571 / liver cancer [ icgc ]
K211 Q211 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K211 T211 Biomuta DOID:1909 / melanoma [ cosmic ]
K269 R269 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K314 Q314 Biomuta DOID:363 / uterine cancer [ tcga ]