iPTMnet Report for Q99973 (TEP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99973 / TEP1_HUMAN
Protein Name Telomerase protein component 1
Gene Name Name: TEP1
Synonyms:TLP1,TP1;
Organism Homo sapiens (Human)

PRO ID PR:Q99973
DAG View
PRO Name telomerase protein component 1 (human)
Definition A telomerase protein component 1 that is encoded in the genome of human.
Short Label hTEP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99973 (TEP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
R143 Methylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
K379 Ubiquitination PhosphoSitePlus
S397 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K508 Acetylation PhosphoSitePlus
K633 Ubiquitination PhosphoSitePlus
S695 Phosphorylation PhosphoSitePlus
T714 Phosphorylation PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
K742 Ubiquitination PhosphoSitePlus
K798 Acetylation PhosphoSitePlus
K808 Acetylation PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
S920 O-Glycosylation GlyGen 35254053
S1058 Phosphorylation PhosphoSitePlus
K1061 Ubiquitination PhosphoSitePlus
K1227 Ubiquitination PhosphoSitePlus
K1339 Ubiquitination PhosphoSitePlus
S1344 Phosphorylation PhosphoSitePlus
S1401 Phosphorylation PhosphoSitePlus
T1402 Phosphorylation PhosphoSitePlus
C1526 Methylation IEDB 31844290
T1847 Phosphorylation PhosphoSitePlus
S1960 Phosphorylation PhosphoSitePlus
S2353 Phosphorylation PhosphoSitePlus
K2508 Ubiquitination PhosphoSitePlus
T2516 Phosphorylation PhosphoSitePlus
S2533 Phosphorylation PhosphoSitePlus
S2536 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S695 Phosphorylation HPRD 18491316
T714 Phosphorylation HPRD 18491316


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K48 E48 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y67 H67 Biomuta [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
R143 H143 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
R143 C143 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K368 R368 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K379 T379 Biomuta DOID:363 / uterine cancer [ icgc ]
S397 Y397 Biomuta DOID:363 / uterine cancer [ icgc ]
T714 M714 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K742 N742 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K798 E798 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K864 N864 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1960 Y1960 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S1960 F1960 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S2353 L2353 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S2533 R2533 Biomuta DOID:363 / uterine cancer [ icgc ]