iPTMnet Report for Q99961 (SH3GL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99961 / SH3G1_HUMAN
Protein Name Endophilin-A2
Gene Name Name: SH3GL1
Synonyms:CNSA1,SH3D2B;
Organism Homo sapiens (Human)

PRO ID PR:Q99961
DAG View
PRO Name endophilin-A2 (human)
Definition An endophilin-A2 that is encoded in the genome of human.
Short Label hSH3GL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99961 (SH3GL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K12 Methylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
K20 Acetylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
C147 S-Nitrosylation dbSNO 19483679
K149 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
R184 Methylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K239 Ubiquitination PhosphoSitePlus
C277 Methylation IEDB 31844290
T278 O-Glycosylation GlyGen 31373491
T279 O-Glycosylation GlyGen 23301498, 32119511, 31492838, ...35132862
S286 O-Glycosylation GlyGen 23301498, 32119511, 31492838, ...35132862, 31373491
S287 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S288 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...17287340, 24275569, 18088087, 20068231
S291 Phosphorylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus   UniProt 23186163
T298 Phosphorylation PhosphoSitePlus   UniProt 23186163
S302 Phosphorylation PhosphoSitePlus
C311 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
Y315 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 16054026
Y315 Phosphorylation A0A059VC25 (FAK) phospho.ELM 16054026
Y315 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 16054026
Y315 Phosphorylation Q05397 (PTK2) PhosphoSitePlus   Signor 16054026
Site PTM Type PTM Enzyme Score Source PMID
S286 Phosphorylation HPRD 20068231
S287 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S288 Phosphorylation HPRD 17322306, 18088087, 18212344, ...18767875, 20058876, 19664995, 19651622, 18669648, 20166139, 17287340, 19415658, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K12 N12 Biomuta DOID:1324 / lung cancer [ cosmic ]
S75 P75 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K76 N76 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K122 * Biomuta DOID:1324 / lung cancer [ cosmic ]
R184 C184 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic ]
C277 Y277 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T278 I278 Biomuta DOID:363 / uterine cancer [ icgc ]
Y315 * Biomuta DOID:10534 / stomach cancer [ cosmic ]