iPTMnet Report for Q99959 (PKP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99959 / PKP2_HUMAN
Protein Name Plakophilin-2
Gene Name Name: PKP2
Organism Homo sapiens (Human)

PRO ID PR:Q99959
DAG View
PRO Name plakophilin-2 (human)
Definition A plakophilin-2 that is encoded in the genome of human.
Short Label hPKP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99959 (PKP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation PhosphoSitePlus
Y12 Phosphorylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
K39 Methylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus   UniProt 20068231
R46 Methylation PhosphoSitePlus   UniProt 24129315
K52 Methylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
T63 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
T80 Phosphorylation PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
S82 Phosphorylation PhosphoSitePlus   UniProt 12941695
Y86 Phosphorylation PhosphoSitePlus
Y88 Phosphorylation PhosphoSitePlus
S102 Phosphorylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
T107 Phosphorylation PhosphoSitePlus
Y108 Phosphorylation PhosphoSitePlus
K112 Methylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
T118 Phosphorylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
R125 Methylation PhosphoSitePlus
T127 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus
S132 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
K134 Ubiquitination PhosphoSitePlus
S135 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S140 Phosphorylation PhosphoSitePlus
S151 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195, 18669648, 24275569, 20068231
S154 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...20068231
S155 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 20068231
Y161 Phosphorylation PhosphoSitePlus
T162 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
Y166 Phosphorylation PhosphoSitePlus
Y168 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S169 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17525332
S172 Phosphorylation PhosphoSitePlus   UniProt 24275569
T177 Phosphorylation PhosphoSitePlus   UniProt 24275569
S183 Phosphorylation PhosphoSitePlus   UniProt 24275569
R193 Methylation PhosphoSitePlus
Y194 Phosphorylation PhosphoSitePlus
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S203 O-Glycosylation GlyGen 30379171, 34019948, 35254053
S203 Phosphorylation PhosphoSitePlus
R204 Methylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
T208 Phosphorylation PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
T242 Phosphorylation PhosphoSitePlus
Y243 Phosphorylation PhosphoSitePlus
T248 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231, ...24275569
K258 Ubiquitination PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
S294 Phosphorylation PhosphoSitePlus   UniProt 23186163
S297 Phosphorylation PhosphoSitePlus
R302 Methylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S329 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231, ...24275569
S342 Phosphorylation PhosphoSitePlus
S358 Phosphorylation PhosphoSitePlus
R390 Methylation PhosphoSitePlus
R395 Methylation PhosphoSitePlus
K405 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
T462 Phosphorylation PhosphoSitePlus
Y597 Phosphorylation PhosphoSitePlus
Y616 Phosphorylation PhosphoSitePlus
Y626 Phosphorylation PhosphoSitePlus
Y631 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
S650 Phosphorylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
Y659 Phosphorylation PhosphoSitePlus
Y686 Phosphorylation PhosphoSitePlus
S693 Phosphorylation PhosphoSitePlus
K736 Ubiquitination PhosphoSitePlus
S744 Phosphorylation PhosphoSitePlus
K747 Ubiquitination PhosphoSitePlus
S761 Phosphorylation PhosphoSitePlus
Y831 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
K864 Ubiquitination PhosphoSitePlus
S870 Phosphorylation PhosphoSitePlus
K874 Ubiquitination PhosphoSitePlus
Y876 Phosphorylation PhosphoSitePlus
S878 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation HPRD 19901323
Y12 Phosphorylation HPRD 19901323
S44 Phosphorylation HPRD 20068231
T80 Phosphorylation HPRD 20166139
Y86 Phosphorylation HPRD 18452278
S132 Phosphorylation HPRD 17525332
S135 Phosphorylation HPRD 20166139, 18669648
S151 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19664995, 19691289, 18669648, 20166139, 19415658, 20068231
S154 Phosphorylation HPRD 20166139, 18691976, 18669648, ...20068231
S155 Phosphorylation HPRD 19413330, 18691976, 19691289, ...18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Y166 Phosphorylation HPRD 19901323
S169 Phosphorylation HPRD 17525332
S197 Phosphorylation HPRD 18669648, 19691289
Y217 Phosphorylation HPRD 19901323
S251 Phosphorylation HPRD 19664994, 19664995, 20068231, ...19691289
S293 Phosphorylation HPRD 20166139
S294 Phosphorylation HPRD 20166139
S329 Phosphorylation HPRD 20166139, 18669648, 20068231
Y686 Phosphorylation HPRD 20068231
S693 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
Y10 Phosphorylation HPRD 19901323
Y12 Phosphorylation HPRD 19901323
S44 Phosphorylation HPRD 20068231
T80 Phosphorylation HPRD 20166139
Y86 Phosphorylation HPRD 18452278
S132 Phosphorylation HPRD 17525332
S135 Phosphorylation HPRD 20166139, 18669648
S151 Phosphorylation HPRD 19413330, 18691976, 19664994, ...19664995, 19691289, 18669648, 20166139, 19415658, 20068231
S154 Phosphorylation HPRD 20166139, 18691976, 18669648, ...20068231
S155 Phosphorylation HPRD 19413330, 18691976, 19691289, ...18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Y166 Phosphorylation HPRD 19901323
S169 Phosphorylation HPRD 17525332
S197 Phosphorylation HPRD 18669648, 19691289
Y217 Phosphorylation HPRD 19901323
S251 Phosphorylation HPRD 19664994, 19664995, 20068231, ...19691289
S293 Phosphorylation HPRD 20166139
S294 Phosphorylation HPRD 20166139
S329 Phosphorylation HPRD 20166139, 18669648, 20068231
K470 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
Y642 Phosphorylation HPRD 20068231
S649 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K37 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S43 N43 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R46 P46 Biomuta DOID:1324 / lung cancer [ cosmic ]
K52 R52 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y130 C130 Biomuta DOID:1319 / brain cancer [ icgc ]
S131 N131 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
S132 F132 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S154 R154 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y161 C161 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S164 N164 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y168 C168 Biomuta DOID:1324 / lung cancer [ icgc ]
S172 T172 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T177 I177 Biomuta DOID:4159 / skin cancer [ cosmic ]
R204 C204 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R204 L204 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R204 H204 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
Y217 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S225 F225 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S251 C251 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T263 M263 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S294 F294 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R390 K390 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
R395 C395 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T459 A459 Biomuta DOID:363 / uterine cancer [ icgc ]
T462 A462 Biomuta DOID:184 / bone cancer [ cosmic ]
K472 N472 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y631 H631 Biomuta [ cosmic ]
K643 E643 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
Y659 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S761 F761 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S870 R870 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K874 E874 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S878 F878 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:8618 / oral cavity cancer [ cosmic ]