Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99952 / PTN18_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 18
Gene Name Name: PTPN18
Synonyms:BDP1;
Organism Homo sapiens (Human)

PRO ID PR:Q99952
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 18 (human)
Definition A tyrosine-protein phosphatase non-receptor type 18 that is encoded in the genome of human.
Short Label hPTPN18
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99952 (PTPN18) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation phospho.ELM   PhosphoSitePlus 16094384
S76 Phosphorylation PhosphoSitePlus
Y281 Phosphorylation P42680 (TEC) PhosphoSitePlus 14679216
Y303 Phosphorylation P42680 (TEC) PhosphoSitePlus 14679216
Y314 Phosphorylation PhosphoSitePlus
T322 Phosphorylation PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
Y354 Phosphorylation P42680 (TEC) PhosphoSitePlus 14679216
T370 Phosphorylation PhosphoSitePlus
T374 Phosphorylation PhosphoSitePlus
T376 Phosphorylation PhosphoSitePlus
S382 Phosphorylation PhosphoSitePlus
Y389 Phosphorylation P42680 (TEC) PhosphoSitePlus 14679216
S390 Phosphorylation PhosphoSitePlus
T393 Phosphorylation PhosphoSitePlus   UniProt 23186163
S419 Phosphorylation PhosphoSitePlus   RLIMS-P 25081058
S423 Phosphorylation PhosphoSitePlus   RLIMS-P 25081058
Y426 Phosphorylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
T458 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation HPRD 16094384
Y281 Phosphorylation P42680 (TEC) HPRD 14679216
Y303 Phosphorylation P42680 (TEC) HPRD 14679216
Y354 Phosphorylation P42680 (TEC) HPRD 14679216
Y389 Phosphorylation HPRD 17016520, 15951569, 19901323
Site PTM Type PTM Enzyme Score Source PMID
K32 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y314 C314 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S390 R390 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]