iPTMnet Report for Q99952 (PTPN18)
Protein Information
| UniProt AC / UniProt ID | Q99952 / PTN18_HUMAN |
| Protein Name | Tyrosine-protein phosphatase non-receptor type 18 |
| Gene Name | Name: PTPN18 Synonyms:BDP1; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q99952 |
| PRO Name | tyrosine-protein phosphatase non-receptor type 18 (human) |
| Definition | A tyrosine-protein phosphatase non-receptor type 18 that is encoded in the genome of human. |
| Short Label | hPTPN18 |
| Category | organism-gene |
DAG ViewQ99952 (PTPN18) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S10 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 16094384 | ||
| S76 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y281 | Phosphorylation | P42680 (TEC) | score2 | PhosphoSitePlus | 14679216 | |
| Y303 | Phosphorylation | P42680 (TEC) | score2 | PhosphoSitePlus | 14679216 | |
| Y314 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T322 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S341 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S345 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y354 | Phosphorylation | P42680 (TEC) | score2 | PhosphoSitePlus | 14679216 | |
| T370 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T374 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T376 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S382 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y389 | Phosphorylation | P42680 (TEC) | score2 | PhosphoSitePlus | 14679216 | |
| S390 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T393 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
| S419 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 25081058 | ||
| S423 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 25081058 | ||
| Y426 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T435 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T458 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S10 | Phosphorylation | score0 | HPRD | 16094384 | ||
| Y281 | Phosphorylation | P42680 (TEC) | score1 | HPRD | 14679216 | |
| Y303 | Phosphorylation | P42680 (TEC) | score1 | HPRD | 14679216 | |
| Y354 | Phosphorylation | P42680 (TEC) | score1 | HPRD | 14679216 | |
| Y389 | Phosphorylation | score0 | HPRD | 17016520, 15951569, 19901323 |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K32 | Ubiquitination | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| Y314 | C314 | Biomuta | DOID:263 / kidney cancer [ cosmic, icgc ] | |
| S390 | N390 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S390 | R390 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] |
