iPTMnet Report for Q99878 (H2AC14)
Protein Information
| UniProt AC / UniProt ID | Q99878 / H2A1J_HUMAN |
| Protein Name | Histone H2A type 1-J |
| Gene Name | Name: H2AC14 Synonyms:H2AFE,HIST1H2AJ; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:Q99878 |
| PRO Name | histone H2A type 1-J (human) |
| Definition | A histone H2A type 1-J that is encoded in the genome of human. |
| Short Label | hH2AC14 |
| Category | organism-gene |
DAG ViewQ99878 (H2AC14) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| Acetylation | score1 | PRO | ||||
| S2 | Acetylation | score3 | UniProt | 15823041, 16457589 | ||
| S2 | Phosphorylation | score2 | PRO UniProt | 15010469 | ||
| K6 | Acetylation | score1 | PRO | 17709392 | ||
| K10 | Acetylation | score1 | PRO | 18552846, 12937907 | ||
| K14 | Ubiquitination | score1 | UniProt | 22713238, 22980979 | ||
| K16 | Ubiquitination | score1 | UniProt | 22713238, 22980979 | ||
| S19 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Q105 | Methylation | score1 | UniProt | 24352239 | ||
| K119 | Acetylation | score1 | PhosphoSitePlus | |||
| K119 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K120 | Ubiquitination | score2 | PRO UniProt | 18400894, 16359901, 15386022, ... | ||
| T121 | Phosphorylation | score2 | PRO UniProt | 19965387, 24140421, 15078818 |
Proteoforms
| PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
|---|---|---|---|---|---|
| PR:000044961 (hHIST1H2AJ/InitMet-/Ac:1) | acK6 | PRO | 17709392 | ||
| PR:000044962 (hHIST1H2AJ/InitMet-/Ubiq:1) | ubK120 | PRO | 15386022, 18400894 | ||
| PR:000044963 (hHIST1H2AJ/InitMet-/Phos:1) | pS2 | PRO | 15010469 | ||
| PR:000044965 (hHIST1H2AJ/InitMet-/Ac:2) | acK10 | PRO | 12937907, 18552846 | ||
| PR:000044970 (hHIST1H2AJ/InitMet-/Phos:2) | pT121 | PRO | 19965387 | ||
| PR:000047752 (hHIST1H2AJ/InitMet-/N6AcLys+) | ac | PRO |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| S2 | Y2 | Biomuta | DOID:363 / uterine cancer [ icgc ] | |
| S2 | F2 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K10 | E10 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] | |
| K16 | N16 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| S19 | Y19 | Biomuta | DOID:4606 / bile duct cancer [ cosmic ] | |
| S19 | F19 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] | |
| S19 | C19 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
| Q105 | H105 | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| Q105 | L105 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| K119 | N119 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] |
