iPTMnet Report for Q99873 (PRMT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID Q99873 / ANM1_HUMAN
Protein Name Protein arginine N-methyltransferase 1
Gene Name Name: PRMT1
Synonyms:HMT2,HRMT1L2,IR1B4;
Organism Homo sapiens (Human)

PRO ID PR:Q99873
DAG View
PRO Name protein arginine N-methyltransferase 1 (human)
Definition A protein arginine N-methyltransferase 1 that is encoded in the genome of human.
Short Label hPRMT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


Q99873 (PRMT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus
Y52 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
K131 Ubiquitination PhosphoSitePlus
K134 Acetylation PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K145 Acetylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K183 Acetylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
R195 Methylation PhosphoSitePlus
Y199 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
R206 Methylation PhosphoSitePlus
C226 Methylation IEDB 31844290
K228 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
C250 Methylation IEDB 31844290
K253 Ubiquitination PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
C272 Methylation IEDB 31844290
K276 Ubiquitination PhosphoSitePlus
S304 Phosphorylation PhosphoSitePlus   UniProt 23186163
S307 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y309 Phosphorylation PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
K313 Acetylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
T315 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y309 Phosphorylation HPRD 18083107
Site PTM Type PTM Enzyme Score Source PMID
Y291 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K113 R113 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S121 G121 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R195 Q195 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y199 H199 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
C226 Y226 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
Y258 H258 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S304 C304 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T310 M310 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T315 M315 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:9253 / gastrointestinal stromal tumor [ cosmic ]